Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00875)
MIC Name Mycoplasma pneumoniae (mycoplasmas)
MIC Synonyms Schizoplasma pneumoniae
Body Site Lung
Lineage Kingdom: Bacteria
Phylum: Tenericutes
Class: Mollicutes
Order: Mycoplasmatales
Family: Mycoplasmataceae
Genus: Mycoplasma
Species: Mycoplasma pneumoniae
Oxygen Sensitivity Facultative anaerobe
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 816498
Description Mycoplasma pneumoniae is a very small bacterium in the class Mollicutes. It is a human pathogen that causes the disease mycoplasma pneumonia, a form of atypical bacterial pneumonia related to cold agglutinin disease. M. pneumoniae is characterized by the absence of a peptidoglycan cell wall and resulting resistance to many antibacterial agents.
External Links Taxonomy ID
2104
Genome Assembly ID
ASM2734v1
GOLD Organism ID
Go0016497
Disease Relevance
          Asthma  [ICD-11: CA23]
             Description Mycoplasma pneumoniae was associated with bronchial asthma. [1]
          Bronchitis  [ICD-11: CA20]
             Description Mycoplasma pneumoniae was associated with chronic lung disease. [1]
Host Genetic Factors (HGFs)
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The higher AMY1-CN has been associated with the abundance of Mycoplasma. [2]
          hsa-miR-222-3p
             HGF ID HGF0195 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-222-3p expression was high in children with Mycoplasma pneumoniae pneumonia. [3]
          rs1800795
             HGF ID HGF1720 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The IL-6 rs1800795 was significantly associated with the risks of mycoplasma pneumoniae pneumonia (MPP) (p-value<0.05). [4]
          rs1799983
             HGF ID HGF1454 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The NOS3 rs1799983 was significantly associated with the risks of mycoplasma pneumoniae pneumonia (MPP) (p-value<0.05). [4]
Host Immune Factors (HIFs)
          Interleukin-1 alpha
             HIF ID HIFM0137 HIF Info       Class Cytokine (Cyt)
             Description MyD88 KO BMDMs infected with Mycoplasma pneumoniae showed complete loss of IL-1(p<0.001). [5]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Mycoplasma pneumoniae infection could trigger IL-1beta secretion. [5]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Mycoplasma pneumoniae infection triggers secretion of several proinflammatory cytokines such as IL-6. [5]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Mycoplasma pneumoniae infection triggers secretion of several proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), IL-6, and, importantly, IL-1Beta. [5]
          Immunoglobulin E
             HIF ID HIFM0271 HIF Info       Class Immunoglobulin (Ig)
             Description Mycoplasma pneumoniae could induce allergy by producing P1-specific immunoglobulin E. [6]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Mycoplasma pneumoniae-derived ADP-ribosylating and vacuolating toxin called community-acquired respiratory distress syndrome (CARDS) toxin is capable of triggering NLRP3 (NLR-family, leucine-rich repeat protein 3) inflammasome activation and interleukin-1 (IL-1) secretion in macrophages. [5]
          NACHT, LRR and PYD domains-containing protein 3
             HIF ID HIFM0180 HIF Info       Class Nod-like receptor (NLR)
             Description NLRP3 is a critical regulator of inflammation and innate immune cell response during Mycoplasma pneumoniae Infection. [5]
          Myeloid differentiation primary response 88 signaling pathway
             HIF ID HIFP0026 HIF Info       Class Signaling pathway (SP)
             Description Proinflammatory gene upregulation during Mycoplasma pneumoniae infection is mediated by the MyD88/NF-kappaB pathway. [5]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description Proinflammatory gene upregulation during Mycoplasma pneumoniae infection is mediated by the MyD88/NF-kappaB pathway. [5]
          G-protein coupled receptor signaling pathway
             HIF ID HIFP0010 HIF Info       Class Signaling pathway (SP)
             Description Thermobifida fusca was associated with GPCR. [7]
          Membrane palmitoylated protein signaling pathway
             HIF ID HIFP0025 HIF Info       Class Signaling pathway (SP)
             Description Thermobifida fusca was associated with MPP. [7]
          T helper type 17 cells
             HIF ID HIFC0080 HIF Info       Class T cells (TCs)
             Description Thermobifida fusca was associated with Th17 immune response. [7]
Environmental Factor(s)
             Disbiome ID
      1558
References
1 Pathogenesis of Mycoplasma pneumoniae: An update. Indian J Med Microbiol. 2016 Jan-Mar;34(1):7-16. doi: 10.4103/0255-0857.174112.
2 Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.Cell Host Microbe. 2019 Apr 10;25(4):553-564.e7. doi: 10.1016/j.chom.2019.03.001.
3 High expression of miR-222-3p in children with Mycoplasma pneumoniae pneumonia. Ital J Pediatr. 2019 Dec 16;45(1):163. doi: 10.1186/s13052-019-0750-7.
4 Association of the ACE, GSTM1, IL-6, NOS3, and CYP1A1 polymorphisms with susceptibility of mycoplasma pneumoniae pneumonia in Chinese children.Medicine (Baltimore). 2017 Apr;96(15):e6642. doi: 10.1097/MD.0000000000006642.
5 NLRP3 Is a Critical Regulator of Inflammation and Innate Immune Cell Response during Mycoplasma pneumoniae Infection. Infect Immun. 2017 Dec 19;86(1):e00548-17. doi: 10.1128/IAI.00548-17. Print 2018 Jan.
6 Mycoplasma pneumoniae induces allergy by producing P1-specific immunoglobulin E.Ann Allergy Asthma Immunol. 2018 Jul;121(1):90-97. doi: 10.1016/j.anai.2018.03.014. Epub 2018 Mar 16.
7 Data mining and systematic pharmacology to reveal the mechanisms of traditional Chinese medicine in Mycoplasma pneumoniae pneumonia treatment. Biomed Pharmacother. 2020 May;125:109900. doi: 10.1016/j.biopha.2020.109900. Epub 2020 Feb 3.

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