General Information of HGF (ID: HGF1720)
HGF Name rs1800795
Source Homo sapiens
HGF Classification Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Gene Location chr7:22727026
SNP in Gene
IL6-AS1
Microbe Species (MIC) Regulated by This HGF
         Mycoplasma genitalium (mycoplasmas) MIC00870
             Description The variant gene IL-6 of innate immunity rs1800795 is significantly associated with the abundance of gut micriobiota Mollicutes (p-value=0.0181). [1]
         Mycoplasma pneumoniae (mycoplasmas) MIC00875
             Description The IL-6 rs1800795 was significantly associated with the risks of mycoplasma pneumoniae pneumonia (MPP) (p-value<0.05). [2]
         Oscillospira sp. A (firmicutes) MIC00933
             Description The IL-6 of innate immunity rs1800795 is significantly associated with the abundance of gut micriobiota Oscillospira (p-value<0.0001). [1]
         Pseudomonas aeruginosa (gamma-proteobacteria) MIC01054
             Description The rs1800795 SNP was significantly associated with the abundance of Pseudomonas aeruginosa (p-value<0.05). [3]
         Ruminococcus sp. (firmicutes) MIC01140
             Description The variant gene IL-6 of innate immunity rs1800795 is significantly associated with the abundance of gut micriobiota Ruminococcaceae (p-value<0.0001). [1]
         Staphylococcus aureus (firmicutes) MIC01208
             Description The variations in rs1800795 in the IL-6 promoter region were associated with the abundance of Staphylococcus aureus (p-value<0.05). [3]
References
1 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
2 Association of the ACE, GSTM1, IL-6, NOS3, and CYP1A1 polymorphisms with susceptibility of mycoplasma pneumoniae pneumonia in Chinese children.Medicine (Baltimore). 2017 Apr;96(15):e6642. doi: 10.1097/MD.0000000000006642.
3 Potential Role of Ocular Microbiome, Host Genotype, Tear Cytokines, and Environmental Factors in Corneal Infiltrative Events in Contact Lens Wearers.Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5752-5761. doi: 10.1167/iovs.18-24845.

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