Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00933)
MIC Name Oscillospira sp. A (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Ruminococcaceae
Genus: .
Species: Oscillospira sp. A
Oxygen Sensitivity Anaerobe
Gram Negative
Description Oscillospira is an undertudied anaerobic bacterial genus from Clostridial cluster IV that has resisted cultivation for over a century since the first time it was observed. In recent years its 16SrRNA gene was identified in several human gut microbiota studies where it was often associated with interesting traits, especially leanness.
External Links Taxonomy ID
227395
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Oscillospira was significantly elevated in autistic children. [1]
          Hyperlipoproteinaemia  [ICD-11: 5C80]
             Description Oscillospira sp. was associated with hypercholesterolemia. [2]
Host Genetic Factors (HGFs)
          TLR2
             HGF ID HGF2319 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of TLR2 increased the abundance of Oscillospira. [3]
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description Gut microbiome Oscillospira differs between high AMY1-CN and low AMY1-CN groups at the OTU Level (p-value<0.05). [4]
          SLC15A1
             HGF ID HGF2354 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of PepT1 could decrease the abundance of Oscillospira. [5]
          NLRP3
             HGF ID HGF2355 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of NLRP3 could significantly increase the abundance of Oscillospira (p-value<0.01). [6]
          rs1800795
             HGF ID HGF1720 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The IL-6 of innate immunity rs1800795 is significantly associated with the abundance of gut micriobiota Oscillospira (p-value<0.0001). [7]
          rs7581129
             HGF ID HGF2121 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7581129 SNP was significantly associated with the relative abundance of Oscillospira (p-value=4.20E-08). [8]
          rs4437359
             HGF ID HGF1676 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4437359 SNP was significantly associated with the abundance of Oscillospira (p-value=0.03601). [9]
Host Immune Factors (HIFs)
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Oscillospira was significantly enriched in the IgA (Low or no IgA binding) consortia. [10]
Environmental Factor(s)
             Disbiome ID
      237
             gutMDisorder ID
      gm0486
References
1 The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder. Int J Mol Sci. 2019 Apr 29;20(9):2115. doi: 10.3390/ijms20092115.
2 Atorvastatin Treatment Modulates the Gut Microbiota of the Hypercholesterolemic Patients. OMICS. 2018 Feb;22(2):154-163. doi: 10.1089/omi.2017.0130.
3 Microbiota determines insulin sensitivity in TLR2-KO mice.Life Sci. 2019 Oct 1;234:116793. doi: 10.1016/j.lfs.2019.116793. Epub 2019 Aug 26.
4 Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.Cell Host Microbe. 2019 Apr 10;25(4):553-564.e7. doi: 10.1016/j.chom.2019.03.001.
5 Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.NPJ Biofilms Microbiomes. 2020 Jul 21;6(1):27. doi: 10.1038/s41522-020-0137-y.
6 Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2.Microbiome. 2019 Aug 22;7(1):116. doi: 10.1186/s40168-019-0733-3.
7 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
8 Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
9 FUT2 genotype and secretory status are not associated with fecal microbial composition and inferred function in healthy subjects.Gut Microbes. 2018 Jul 4;9(4):357-368. doi: 10.1080/19490976.2018.1445956. Epub 2018 Apr 27.
10 IgA Function in Relation to the Intestinal Microbiota.Annu Rev Immunol. 2018 Apr 26;36:359-381. doi: 10.1146/annurev-immunol-042617-053238. Epub 2018 Jan 26.

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