General Information of HIF (ID: HIFM0271)
HIF Name	Immunoglobulin E
HIF Synonym(s)	IgE
HIF Classification	Immunoglobulin (Ig)
Description	Immunoglobulin E(IgE) , like other immunoglobulins, is produced by B cells and plasma cells(usually) in response to an antigenic stimulus.				[1]

Microbe Species (MIC) Regulated by This HIF
Actinobacteria (actinobacteria)			MIC00025
Description	IgE immune responses was associated with Actinobacteria.				[2]
Akkermansia sp. (verrucomicrobia)			MIC00057
Description	Akkermansia resulted increased in non-IgE-mediated CMA(cows milk allergy) patients.				[3]
Alistipes finegoldii (CFB bacteria)			MIC00064
Description	A gut microbiota dysbiosis was found in non-IgE-mediated cows milk allergy, driven by an enrichment of Alistipes.				[3]
Ascaris lumbricoides (nematodes)			MIC01799
Description	IgE immune responses was associated with Ascaris lumbricoides.				[4]
Bacteroides fragilis (CFB bacteria)			MIC00158
Description	high Bacteroides fragilis is positively associated with IgE.				[5]
Bacteroides sp. (CFB bacteria)			MIC00176
Description	Bacteroidales consortium could suppress IgE binding to the fecal bacteria of treated FA Il4raF709 mice.				[6]
Bifidobacterium breve (actinobacteria)			MIC00210
Description	IgE immune responses was associated with Bifidobacterium breve.				[7]
Bifidobacterium longum (actinobacteria)			MIC00232
Description	The relative abundance of Bifidobacterium longum showed an inverse association with atopic sensitization, the number of allergen-specific IgEs and the development of allergy (p = 0.023, p = 0.026, p = 0.022).				[8]
Bilophila wadsworthia (delta-proteobacteria)			MIC00235
Description	Bilophila is significantly enriched in IgE-mediated compared to non-IgE-mediated CMA(cows milk allergy) subjects.				[3]
Blautia coccoides (firmicutes)			MIC00394
Description	IgE immune responses was associated with Clostridium coccoides.				[7]
Blautia producta (firmicutes)			MIC00981
Description	Blautia resulted increased in non-IgE-mediated CMA(cows milk allergy) patients.				[3]
Chlamydia pneumoniae (chlamydias)			MIC00350
Description	The titer of Chlamydophila pneumoniaespecific IgE levels in asthmatic patients significantly correlated with asthma severity.				[9]
Clostridium sp. (firmicutes)			MIC00418
Description	Clostridiales could suppress the IgE anti-bacterial response.				[6]
Coprococcus eutactus (firmicutes)			MIC00443
Description	Coprococcus eutactus is negatively associated with IgE level.				[10]
Coriobacteriaceae (actinobacteria)			MIC01911
Description	IgE immune responses was associated with Coriobacteriaceae.				[2]
Cutibacterium acnes (actinobacteria)			MIC01031
Description	A low relative abundance of Actinobacteria phylum (Propionibacterium acnes)is associated with individuals with high total serum IgE levels.				[11]
Escherichia coli (enterobacteria)			MIC00516
Description	Low Escherichia coli is positively associated with IgE immune responses.				[5]
Eubacterium rectale (firmicutes)			MIC00578
Description	IgE immune responses was associated with Eubacterium rectale.				[7]
Eubacterium sp. (firmicutes)			MIC00581
Description	Eubacterium resulted increased in non-IgE-mediated CMA(cows milk allergy) patients.				[3]
Faecalibacterium prausnitzii (firmicutes)			MIC00590
Description	IgE immune responses was associated with maturation of Faecalibacterium prausnitzii.				[8]
Faecalicatena fissicatena (firmicutes)			MIC00584
Description	IgE immune responses was associated with Eubacterium fissicatena.				[2]
Fusobacterium sp. (fusobacteria)			MIC00613
Description	Fusobacterium is significantly enriched in IgE-mediated compared to non-IgE-mediated CMA(cows milk allergy) subjects.				[3]
Giardia intestinalis (diplomonads)			MIC00633
Description	IgE immune responses was associated with Giardia intestinalis.				[12]
Haemophilus influenzae (gamma-proteobacteria)			MIC00652
Description	The abundance of Haemophilus influenzae is associated with IgE immune response.				[13]
Haemophilus sp. (gamma-proteobacteria)			MIC01768
Description	Haemophilus sp. negatively correlate to IgE but positively correlated to hospital stay				[14]
Heligmosomoides polygyrus bakeri (nematodes)			MIC01865
Description	IgE immune responses is associated with Heligmosomoides polygyrus bakeri.				[15]
Histophilus somni (gamma-proteobacteria)			MIC00655
Description	Specificity of IgE antibody could responses to Haemophilus somnus infection of calves.				[16]
Lactobacillus pentosus (firmicutes)			MIC00728
Description	Oral administration of Lactobacillus pentosus KF340 in mice with atopic dermatitis reduced cellular infiltration in affected ear lobes and serum IgE levels.				[17]
Lactobacillus rhamnosus (firmicutes)			MIC00732
Description	IgE immune responses was associated with Lactobacillus rhamnosus.				[3]
Leuconostoc mesenteroides (firmicutes)			MIC00766
Description	Leuconostoc mesenteroides subsp. mesenteroides administration to mice, beginning either before or after the development of OVA sensitization, increased OVA-restimulated IFN-Gamma production in the splenocytes and reduced serum total and OVA-specific IgE levels.				[18]
Mycoplasma pneumoniae (mycoplasmas)			MIC00875
Description	Mycoplasma pneumoniae could induce allergy by producing P1-specific immunoglobulin E.				[19]
Nippostrongylus brasiliensis (nematodes)			MIC01803
Description	The abundance of Nippostrongylus brasiliensisis associated with IgE immune response.				[20]
Pantoea agglomerans (enterobacteria)			MIC00944
Description	The abundance of Pantoea agglomerans is associated with IgG immune responses.				[21]
Porphyromonas gingivalis (CFB bacteria)			MIC01000
Description	The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin E(lgE).				[22]
Raoultella planticola (enterobacteria)			MIC01079
Description	Raoultella resulted increased in non-IgE-mediated CMA(cows milk allergy) patients.				[3]
Ruminococcus sp. (firmicutes)			MIC01140
Description	IgE immune responses was associated with Ruminococcaceae.				[2]
Salmonella enterica subsp. enterica (enterobacteria)			MIC01154
Description	In Salmonella.Enteritidis-infected patients, systemic IgE concentration showed a significant increase.				[23]
Staphylococcus aureus (firmicutes)			MIC01208
Description	An increase in Staphylococcus aureus is associated with high total IgE levels.				[11]
Strongyloides stercoralis (nematodes)			MIC01798
Description	Infections with Strongyloides stercoralis typically cause elevated levels of serum immunoglobulin E (IgE) and eosinophils.				[24]
Subdoligranulum variabile (firmicutes)			MIC01286
Description	IgE immune responses is associated with Subdoligranulum variabile.				[6]
Toxocara canis (nematodes)			MIC01800
Description	Toxocara canis-infected dogs exhibited higher levels of IgG and IgE levels against Toxocara canis.				[25]
Trichinella spiralis (nematodes)			MIC01802
Description	Hyper IgE could impaire protection against Trichinella spiralis.				[26]

References
1	Immunoglobulin E, what is it good for Ann Allergy Asthma Immunol. 2016 Mar;116(3):183-7. doi: 10.1016/j.anai.2015.10.026.
2	Microbiota and Derived Parameters in Fecal Samples of Infants with Non-IgE Cow's Milk Protein Allergy under a Restricted Diet.Nutrients. 2018 Oct 11;10(10):1481. doi: 10.3390/nu10101481.
3	Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow's milk allergy.Sci Rep. 2018 Aug 21;8(1):12500. doi: 10.1038/s41598-018-30428-3.
4	Classification of Wheezing Children in Rural Bangladesh by Intensity of Ascaris Infection, Total and Specific IgE Levels, History of Pneumonia, and Other Risk Factors.J Immunol Res. 2019 Dec 5;2019:4236825. doi: 10.1155/2019/4236825. eCollection 2019.
5	Modelling bacterial transmission in human allergen-specific IgE sensitization.Lett Appl Microbiol. 2012 May;54(5):447-54. doi: 10.1111/j.1472-765X.2012.03229.x. Epub 2012 Mar 19.
6	Microbiota therapy acts via a regulatory T cell MyD88/RORt pathway to suppress food allergy. Nat Med. 2019 Jul;25(7):1164-1174. doi: 10.1038/s41591-019-0461-z. Epub 2019 Jun 24.
7	A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infants.Pediatr Res. 2018 Mar;83(3):677-686. doi: 10.1038/pr.2017.270. Epub 2017 Dec 6.
8	Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life.Front Immunol. 2019 Oct 23;10:2494. doi: 10.3389/fimmu.2019.02494. eCollection 2019.
9	Chlamydia pneumoniae Infection and Inflammatory Diseases. For Immunopathol Dis Therap. 2016;7(3-4):237-254. doi: 10.1615/ForumImmunDisTher.2017020161.
10	Impact of a 3-Months Vegetarian Diet on the Gut Microbiota and Immune Repertoire.Front Immunol. 2018 Apr 27;9:908. doi: 10.3389/fimmu.2018.00908. eCollection 2018.
11	Dysbiosis of Inferior Turbinate Microbiota Is Associated with High Total IgE Levels in Patients with Allergic Rhinitis.Infect Immun. 2018 Mar 22;86(4):e00934-17. doi: 10.1128/IAI.00934-17. Print 2018 Apr.
12	Autosomal-Recessive Hyper-IgE Syndrome.Indian J Dermatol. 2018 Jan-Feb;63(1):79-81. doi: 10.4103/ijd.IJD_445_16.
13	Anti-bacterial IgE in the antibody responses of house dust mite allergic children convalescent from asthma exacerbation.Clin Exp Allergy. 2009 Aug;39(8):1170-8. doi: 10.1111/j.1365-2222.2009.03252.x. Epub 2009 Apr 17.
14	Oral microbiota dysbiosis and its association with Henoch-Schnlein Purpura in children.Int Immunopharmacol. 2018 Dec;65:295-302. doi: 10.1016/j.intimp.2018.10.017. Epub 2018 Oct 17.
15	T Follicular Helper Cell-Derived IL-4 Is Required for IgE Production during Intestinal Helminth Infection.J Immunol. 2017 Jul 1;199(1):244-252. doi: 10.4049/jimmunol.1700141. Epub 2017 May 22.
16	Specificity of IgG and IgE antibody responses to Haemophilus somnus infection of calves.Vet Immunol Immunopathol. 2006 Sep 15;113(1-2):191-9. doi: 10.1016/j.vetimm.2006.05.003. Epub 2006 Jul 7.
17	Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells. Immune Netw. 2019 Dec 26;19(6):e39. doi: 10.4110/in.2019.19.e39. eCollection 2019 Dec.
18	Induction of Th1 cytokines by Leuconostoc mesenteroides subsp. mesenteroides (KCTC 3100) under Th2-type conditions and the requirement of NF-kappaB and p38/JNK. Cytokine. 2009 May;46(2):283-9. doi: 10.1016/j.cyto.2009.02.005. Epub 2009 Mar 18.
19	Mycoplasma pneumoniae induces allergy by producing P1-specific immunoglobulin E.Ann Allergy Asthma Immunol. 2018 Jul;121(1):90-97. doi: 10.1016/j.anai.2018.03.014. Epub 2018 Mar 16.
20	T-cell-independent and T-cell-dependent IgE responses to the nematode Nippostrongylus brasiliensis: comparison of serum IgE and mast-cell-bound IgE.Immunology. 1995 Nov;86(3):351-5.
21	Improvement of allergic dermatitis via regulation of the Th1/Th2 immune system balance by macrophages activated with lipopolysaccharide derived from Pantoea agglomerans (IP-PA1). Anticancer Res. 2009 Nov;29(11):4867-70.
22	Immunoglobulin-degrading enzymes in localized juvenile periodontitis.J Periodontal Res. 1992 May;27(3):176-83. doi: 10.1111/j.1600-0765.1992.tb01666.x.
23	Differential induction of total IgE by two Salmonella enterica serotypes.Front Cell Infect Microbiol. 2015 May 26;5:43. doi: 10.3389/fcimb.2015.00043. eCollection 2015.
24	Normal serum IgE levels and eosinophil counts exhibited during Strongyloides stercoralis infection.Parasitol Int. 2017 Feb;66(1):807-812. doi: 10.1016/j.parint.2016.10.004. Epub 2016 Oct 12.
25	A Toxocara canis infection influences the immune response to house dust mite allergens in dogs.Vet Immunol Immunopathol. 2018 Aug;202:11-17. doi: 10.1016/j.vetimm.2018.06.009. Epub 2018 Jun 11.
26	Impaired protection against Trichinella spiralis in mice with high levels of IgE.Parasitol Int. 2014 Apr;63(2):332-6. doi: 10.1016/j.parint.2013.12.004. Epub 2013 Dec 15.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.