Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00590)
MIC Name Faecalibacterium prausnitzii (firmicutes)
MIC Synonyms Fusobacterium prausnitzii
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Ruminococcaceae
Genus: Faecalibacterium
Species: Faecalibacterium prausnitzii
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative; Acetate converted to butyrate
Gram Structurally positive but stains negative
Host Relationship Commensal
Genome Size (bp) 3080849
Description Faecalibacterium prausnitzii, formerly classified as Fusobacterium prausnitzii, is a non-spore forming and non-motile obligate anaerobic, Gram-positive bacterium. Faecalibacterium prausnitzii is an important commensal bacterium of the human gut flora. Recent medical research has suggested that low levels of F.prausnitzii may be associoted with Crohn's disease and other metabolic diseases.
External Links Taxonomy ID
853
Genome Assembly ID
ASM15438v1
GOLD Organism ID
Go0023470
Disease Relevance
          Atherosclerotic cardiovascular disease  [ICD-11: BA5Z]
             Description Faecalibacterium prausnitzii was associated with genetic variants in Atherosclerotic cardiovascular disease. [1]
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Feacalibacterium prausnitzii was lower in feces of children with autism spectrum disorder. [2]
          Crohn disease  [ICD-11: DD70]
             Description A reduced abundance of Fecalibacterium prausnitzii was associated with an ileal Crohns disease phenotype. [3]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Faecalibacterium prausnitzi was decreased in inflammatory bowel disease. [4]
          Obesity  [ICD-11: 5B81]
             Description Faecalibacterium prausnitzii were significantly higher in the obese compared with the non-obese participants [5]
          Retinal artery occlusions  [ICD-11: 9B74]
             Description Faecalibacterium prausnitzii was relatively enriched in patients with retinal artery occlusion. [6]
          Rheumatoid arthritis  [ICD-11: FA20]
             Description Faecalibacterium was associated with genetic variants in Rheumatoid Arthritis. [1]
          Type 2 diabetes mellitus  [ICD-11: 5A11]
             Description Faecalibacterium prausnitzii was associated with genetic variants in Type 2 diabetes. [1]
          Ulcerative colitis  [ICD-11: DD71]
             Description Faecalibacterium prausnitzii was reduced in ulcerative colitis. [7]
Host Genetic Factors (HGFs)
          SMARCAD1
             HGF ID HGF2342 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of SMARCAD1 was significantly associated with a decrease of Faecalibacterium prausnitzii (p-value<0.05). [8]
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description Gut microbiome Faecalibacterium prausnitzii differs between high AMY1-CN and low AMY1-CN groups at the OTU Level (p-value<0.05). [9]
          rs7486170
             HGF ID HGF1641 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7486170 SNP was significantly associated with the abundance of Faecalibacterium prausnitzii (p-value=4.38E-08). [10]
          rs571312
             HGF ID HGF2159 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The variant gene MC4R of innate immunity rs571312 is significantly associated with the abundance of gut micriobiota Faecalibacterium prausnitzii (p-value=0.0003). [11]
          rs4381430
             HGF ID HGF2232 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs4381430 SNP was significantly associated with the abundance of Faecalibacterium prausnitzii (p-value=0.01175). [12]
          rs3733890
             HGF ID HGF1908 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs3733890 SNP was significantly associated with the abundance of Faecalibacterium prausnitzii (p-value=5.09E-07). [10]
          rs2763309
             HGF ID HGF1667 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2763309 SNP was significantly associated with the abundance of Faecalibacterium prausnitzii (p-value=1.37E-06). [10]
          rs2136233
             HGF ID HGF1525 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2136233 SNP was significantly associated with the abundance of Faecalibacterium prausnitzii (p-value=9.93E-08). [10]
          rs17079032
             HGF ID HGF2157 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs17079032 SNP was significantly associated with the abundance of Faecalibacterium prausnitzii (p-value=6.21E-08). [10]
          rs1346183
             HGF ID HGF1613 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1346183 SNP was significantly associated with the abundance of Faecalibacterium prausnitzii (p-value=3.21E-08). [10]
          rs1320561
             HGF ID HGF2106 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1320561 SNP was significantly associated with the abundance of Faecalibacterium prausnitzii (p-value=9.08E-07). [10]
          rs12915891
             HGF ID HGF1307 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12915891 SNP was significantly associated with the abundance of Faecalibacterium prausnitzii (p-value=1.05E-06). [10]
          rs12776647
             HGF ID HGF1951 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12776647 SNP was significantly associated with the abundance of Faecalibacterium prausnitzii (p-value=9.58E-08). [10]
          rs6920220
             HGF ID HGF2532 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6920220 SNP is associated with the abundance of Faecalibacterium prausnitzii. [13]
          rs925255
             HGF ID HGF2557 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs925255 SNP is associated with the abundance of Faecalibacterium prausnitzii. [13]
          rs5743289
             HGF ID HGF2558 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs5743289 SNP is associated with the abundance of Faecalibacterium prausnitzii. [13]
Host Immune Factors (HIFs)
          High mobility group nucleosome-binding domain-containing protein 2
             HIF ID HIFM0118 HIF Info       Class Antimicrobial peptide (AMP)
             Description Greater expression of HMGN2 was noted in higher abundance of Faecalibacterium prauznitzii responders. [14]
          Polypeptide YY
             HIF ID HIFM0194 HIF Info       Class Antimicrobial peptide (AMP)
             Description The short chain fatty acids (SCFAs), produced in anaerobe conditions by Faecalibacterium prausnitzii, triggered polypeptide YY release by gut mucosal cells. [15]
          Interferon-2
             HIF ID HIFM0141 HIF Info       Class Cytokine (Cyt)
             Description Faecalibacterium prausnitzii is associated with IL-2. [16]
          Interferon-4
             HIF ID HIFM0149 HIF Info       Class Cytokine (Cyt)
             Description Faecalibacterium prausnitzii is associated with IL-4. [16]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Faecalibacterium prausnitzii is associated with IL-6. [16]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Faecalibacterium prausnitzii is associated with IL-8. [16]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description At the species level, Faecalibacterium prausnitzii is associated with TNF-Alpha. [16]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description At the species level, Faecalibacterium prausnitzii is associated with IFN-Gamma. [16]
          Interleukin-1
             HIF ID HIFM0263 HIF Info       Class Cytokine (Cyt)
             Description At the species level, Faecalibacterium prausnitzii is associated with IL-1. [16]
          Immunoglobulin E
             HIF ID HIFM0271 HIF Info       Class Immunoglobulin (Ig)
             Description IgE immune responses was associated with maturation of Faecalibacterium prausnitzii. [17]
          FOXP3+ regulatory T cells
             HIF ID HIFC0033 HIF Info       Class T cells (TCs)
             Description Faecalibacterium prausnitzii induced Foxp3+ Tregulatory cells to produce short-chain fatty acid butyrate. [18]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Relative abundance of Faecalibacterium prausnitzii was associated with CD4+ T-cell counts. [16]
          CD4+CD8+FOXP3 regulatory T cells
             HIF ID HIFC0194 HIF Info       Class T cells (TCs)
             Description Faecalibacterium prausnitzii is related to the accumulation of CD4+CD8+FOXP3 Treg cells in the colon. [19]
          IL-10-CD4+CD8+ regulatory T cells
             HIF ID HIFC0195 HIF Info       Class T cells (TCs)
             Description Faecalibacterium prausnitzii is shown to promote the accumulation of IL-10-expressingCD4+CD8+ regulatory T cells in the colon and the blood of humans. [19]
          Toll-like receptor
             HIF ID HIFM0001 HIF Info       Class Toll-like receptor (TLR)
             Description Faecalibacterium prausnitzii is associated with the activation of TLR system. [16]
Environmental Factor(s)
             Disbiome ID
      6
             gutMDisorder ID
      gm0327
References
1 M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases. bioRxiv, 2019.
2 Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders. Anaerobe. 2018 Feb;49:121-131. doi: 10.1016/j.anaerobe.2017.12.007. Epub 2017 Dec 22.
3 Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models. Gut. 2010 Dec;59(12):1635-42. doi: 10.1136/gut.2010.215665. Epub 2010 Oct 6.
4 Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol. 2017 Jul 7;23(25):4548-4558. doi: 10.3748/wjg.v23.i25.4548.
5 Quantitative differences in intestinal Faecalibacterium prausnitzii in obese Indian children. Br J Nutr. 2010 Feb;103(3):335-8. doi: 10.1017/S0007114509992182. Epub 2009 Oct 23.
6 Retinal artery occlusion is associated with compositional and functional shifts in the gut microbiome and altered trimethylamine-N-oxide levels. Sci Rep. 2019 Oct 25;9(1):15303. doi: 10.1038/s41598-019-51698-5.
7 Influence of Microbiota on Intestinal Immune System in Ulcerative Colitis and Its Intervention. Front Immunol. 2017 Nov 28;8:1674. doi: 10.3389/fimmu.2017.01674. eCollection 2017.
8 Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium.Genome Biol. 2020 Mar 11;21(1):64. doi: 10.1186/s13059-020-01976-7.
9 Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.Cell Host Microbe. 2019 Apr 10;25(4):553-564.e7. doi: 10.1016/j.chom.2019.03.001.
10 Genetic Determinants of the Gut Microbiome in UK Twins.Cell Host Microbe. 2016 May 11;19(5):731-43. doi: 10.1016/j.chom.2016.04.017.
11 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
12 FUT2 genotype and secretory status are not associated with fecal microbial composition and inferred function in healthy subjects.Gut Microbes. 2018 Jul 4;9(4):357-368. doi: 10.1080/19490976.2018.1445956. Epub 2018 Apr 27.
13 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
14 Microbiome-Based Biomarkers for IBD.Inflamm Bowel Dis. 2020 Apr 20:izaa071. doi: 10.1093/ibd/izaa071. Online ahead of print.
15 Targeting patients' microbiota with probiotics and natural fibers in adults and children with constipation.Eur Rev Med Pharmacol Sci. 2018 Oct;22(20):7045-7057. doi: 10.26355/eurrev_201810_16177.
16 Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients. Front Microbiol. 2018 Jul 2;9:1451. doi: 10.3389/fmicb.2018.01451. eCollection 2018.
17 Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life.Front Immunol. 2019 Oct 23;10:2494. doi: 10.3389/fimmu.2019.02494. eCollection 2019.
18 A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function.Gut Microbes. 2015 Jul 4;6(4):234-42. doi: 10.1080/19490976.2015.1056973.
19 Development and maintenance of intestinal regulatory T cells.Nat Rev Immunol. 2016 May;16(5):295-309. doi: 10.1038/nri.2016.36. Epub 2016 Apr 18.

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