Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0118)
HIF Name	High mobility group nucleosome-binding domain-containing protein 2
HIF Synonym(s)	Hmgn2, Non-histone chromosomal protein HMG-17
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	DNA-binding
Description	HMGN2 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.		[1]
Pfam	HMG14 and HMG17 (PF01101 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	HMGN2_HUMAN
	APD ID	AP02234

Microbe Species (MIC) Regulated by This HIF
Faecalibacterium prausnitzii (firmicutes)		MIC00590
Description	Greater expression of HMGN2 was noted in higher abundance of Faecalibacterium prauznitzii responders.		[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Microbiome-Based Biomarkers for IBD.Inflamm Bowel Dis. 2020 Apr 20:izaa071. doi: 10.1093/ibd/izaa071. Online ahead of print.

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