General Information of HIF (ID: HIFM0194)
HIF Name	Polypeptide YY
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Hormone
Description	Polypeptide YY/skin-polypeptide Y human LL-29 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Pfam	Pancreatic hormone peptide (PF00159 )
Pathway	Neuroactive ligand-receptor interaction (hsa04080 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	PYY_HUMAN

Microbe Species (MIC) Regulated by This HIF
Bifidobacterium sp. (actinobacteria)			MIC00224
Description	The short chain fatty acids (SCFAs), produced in anaerobe conditions by Bifidobacteria, triggered polypeptide YY release by gut mucosal cells.				[2]
Clostridia (firmicutes)			MIC01851
Description	The short chain fatty acids (SCFAs), produced in anaerobe conditions by Clostridia, triggered polypeptide YY release by gut mucosal cells.				[2]
Faecalibacterium prausnitzii (firmicutes)			MIC00590
Description	The short chain fatty acids (SCFAs), produced in anaerobe conditions by Faecalibacterium prausnitzii, triggered polypeptide YY release by gut mucosal cells.				[2]

References
1	Antimicrobial peptides and the skin immune defense system.J Allergy Clin Immunol. 2008 Aug;122(2):261-6. doi: 10.1016/j.jaci.2008.03.027. Epub 2008 Apr 25.
2	Targeting patients' microbiota with probiotics and natural fibers in adults and children with constipation.Eur Rev Med Pharmacol Sci. 2018 Oct;22(20):7045-7057. doi: 10.26355/eurrev_201810_16177.

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