Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00581)
MIC Name Eubacterium sp. (firmicutes)
Body Site Vagina
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Eubacteriaceae
Genus: Eubacterium
Species: Eubacterium sp.
Oxygen Sensitivity Anaerobe
Gram Positive
Host Relationship Pathogen
Description Eubacterium sp. is a species of genus Eubacterium. Species from this genus have been isolated from women with bacterial vaginosis.
External Links Taxonomy ID
142586
GOLD Organism ID
Go0546682
Disease Relevance
          Periodontal disease  [ICD-11: DA0C]
             Description Subjects with Refractory periodontitis had high frequency of Eubacterium sp.. [1]
          Type 2 diabetes mellitus  [ICD-11: 5A11]
             Description Eubacterium was associated with genetic variants in Type 2 diabetes. [2]
Host Genetic Factors (HGFs)
          C4B
             HGF ID HGF2348 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The low C4B-CN has been significantly associated with the high abundance of Eubacterium (p-value<0.05). [3]
          rs890100
             HGF ID HGF2119 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs890100 SNP was significantly associated with the abundance of Eubacterium (p-value=2.68E-06). [4]
          rs7605943
             HGF ID HGF2118 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7605943 SNP was significantly associated with the abundance of Eubacterium (p-value=2.68E-06). [4]
          rs7580218
             HGF ID HGF2114 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7580218 SNP was significantly associated with the abundance of Eubacterium (p-value=2.68E-06). [4]
          rs28473221
             HGF ID HGF2151 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs28473221 SNP was significantly associated with the relative abundance of Eubacterium (p-value=9.28E-09). [5]
          rs2288012
             HGF ID HGF1401 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs2288012 SNP is significantly associated with the abundance of Eubacterium (p-value=7.03E-06). [6]
          rs2162025
             HGF ID HGF2116 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs2162025 SNP is significantly associated with the abundance of Eubacterium (p-value=2.75E-06). [4]
          rs1978531
             HGF ID HGF2117 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1978531 SNP is significantly associated with the abundance of Eubacterium (p-value=5.59E-06). [4]
          rs17268931
             HGF ID HGF2115 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs17268931 SNP is significantly associated with the abundance of Eubacterium (p-value=2.68E-06). [4]
          rs17048179
             HGF ID HGF2111 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs17048179 SNP is significantly associated with the abundance of Eubacterium (p-value=7.36E-06). [4]
          rs17039629
             HGF ID HGF2113 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs17039629 SNP is significantly associated with the abundance of Eubacterium (p-value=3.84E-06). [4]
          rs10490411
             HGF ID HGF2112 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs10490411 SNP is significantly associated with the abundance of Eubacterium (p-value=3.84E-06). [4]
Host Immune Factors (HIFs)
          Immunoglobulin E
             HIF ID HIFM0271 HIF Info       Class Immunoglobulin (Ig)
             Description Eubacterium resulted increased in non-IgE-mediated CMA(cows milk allergy) patients. [7]
Environmental Factor(s)
             Disbiome ID
      59
             gutMDisorder ID
      gm0309
References
1 Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray. J Periodontol. 2009 Sep;80(9):1421-32. doi: 10.1902/jop.2009.090185.
2 M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases. bioRxiv, 2019.
3 C4B gene influences intestinal microbiota through complement activation in patients with paediatric-onset inflammatory bowel disease.Clin Exp Immunol. 2017 Dec;190(3):394-405. doi: 10.1111/cei.13040. Epub 2017 Sep 25.
4 Genome-Wide Association Studies of the Human Gut Microbiota.PLoS One. 2015 Nov 3;10(11):e0140301. doi: 10.1371/journal.pone.0140301. eCollection 2015.
5 Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
6 Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.Gut. 2020 Jul 10:gutjnl-2019-319706. doi: 10.1136/gutjnl-2019-319706. Online ahead of print.
7 Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow's milk allergy.Sci Rep. 2018 Aug 21;8(1):12500. doi: 10.1038/s41598-018-30428-3.

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