Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01286)
MIC Name Subdoligranulum variabile (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Ruminococcaceae
Genus: Subdoligranulum
Species: Subdoligranulum variabile
Oxygen Sensitivity Strictly anaerobe
Microbial Metabolism Fermentative
Gram Negative
Genome Size (bp) 3237471
Description Subdoligranulum variabile is a strictly anaerobic, Gram negative, catalase negative, nonmotile and nonsporeorming species of genus subdoligranulum. The cells have variable forms (from circular, ellipsoid to drop-like shapes) and are coccoid.
External Links Taxonomy ID
214851
Genome Assembly ID
ASM15795v1
GOLD Organism ID
Go0000882
Disease Relevance
          Food hypersensitivity  [ICD-11: 4A85]
             Description Subdoligranulum variabile suppressed food allergy. [1]
          Non-alcoholic fatty liver disease  [ICD-11: DB92]
             Description The abundance of Subdoligranulum was decreased in the nonalcoholic fatty liver disease. [2]
          Type 2 diabetes mellitus  [ICD-11: 5A11]
             Description Subdoligranulum was associated with genetic variants in Type 2 diabetes. [3]
Host Genetic Factors (HGFs)
          rs266729
             HGF ID HGF1939 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The variant gene ADIPOQ of innate immunity rs266729 is significantly associated with the abundance of gut micriobiota Subdoligranulum variabile (p-value=0.0101). [4]
Host Immune Factors (HIFs)
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description After stimulation with Subdoligranulum variabile, IL-10 release from PI-IBS patients was significantly increased. [5]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description IL-1beta release from PI-IBS(post-infectious irritable bowel syndrome) patients was significantly increased after stimulation with Subdoligranulum variabile. [5]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description The abundance of Subdoligranulum variabile is associated with TNF-Alpha. [5]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description The abundance of Subdoligranulum variabile is associated with IFN-Gamma. [5]
          Immunoglobulin E
             HIF ID HIFM0271 HIF Info       Class Immunoglobulin (Ig)
             Description IgE immune responses is associated with Subdoligranulum variabile. [1]
          CD16+ Natural Killer cells
             HIF ID HIFC0094 HIF Info       Class Natural killer cells (NKCs)
             Description The increased proportion of CD16+ NK cells was associated with the decrease of gut commensal bacteria(Subdoligranulum). [6]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Relative abundance of Subdoligranulum was associated with CD4+ T-cell counts. [7]
          CD8+ HLADR+ T cells
             HIF ID HIFC0072 HIF Info       Class T cells (TCs)
             Description Subdoligranulum is positively correlated with CD8+ HLA-DR+ T-cell counts and percentages. [7]
          CD8+CD38+ T cells
             HIF ID HIFC0074 HIF Info       Class T cells (TCs)
             Description Subdoligranulum is positively correlated with CD8+CD38+ T-cells. [7]
Environmental Factor(s)
             Disbiome ID
      54
             gutMDisorder ID
      gm0628
References
1 Microbiota therapy acts via a regulatory T cell MyD88/RORt pathway to suppress food allergy. Nat Med. 2019 Jul;25(7):1164-1174. doi: 10.1038/s41591-019-0461-z. Epub 2019 Jun 24.
2 [Correlation analysis of gut microbiota and biochemical indexes in patients with non-alcoholic fatty liver disease]. Zhonghua Gan Zang Bing Za Zhi. 2019 May 20;27(5):369-375. doi: 10.3760/cma.j.issn.1007-3418.2019.05.009.
3 M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases. bioRxiv, 2019.
4 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
5 Cytokine Response after Stimulation with Key Commensal Bacteria Differ in Post-Infectious Irritable Bowel Syndrome (PI-IBS) Patients Compared to Healthy Controls. PLoS One. 2015 Sep 14;10(9):e0134836. doi: 10.1371/journal.pone.0134836. eCollection 2015.
6 Dysbiosis of gut microbiome affecting small intestine morphology and immune balance: a rhesus macaque model.Zool Res. 2020 Jan 18;41(1):20-31. doi: 10.24272/j.issn.2095-8137.2020.004.
7 Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients. Front Microbiol. 2018 Jul 2;9:1451. doi: 10.3389/fmicb.2018.01451. eCollection 2018.

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