General Information of HIF (ID: HIFC0074)
HIF Name	CD8+CD38+ T cells
HIF Synonym(s)	CD8+CD38+ T-cells, CD8+CD38+ T cells
HIF Classification	T cells (TCs)
Description	CD38 is commonly regarded as a T-cell activation marker, and circulating CD38 + CD8 + T cells have been strongly correlated with disease progression in untreated HIV infection [ 3, 4 ]. Upon suppressive cART, levels of CD38 + CD8 + T cells remain abnormally elevated [ 5 ], and yet their prognostic significance is less clear				[]

Microbe Species (MIC) Regulated by This HIF
Subdoligranulum variabile (firmicutes)			MIC01286
Description	Subdoligranulum is positively correlated with CD8+CD38+ T-cells.				[1]

References
1	Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients. Front Microbiol. 2018 Jul 2;9:1451. doi: 10.3389/fmicb.2018.01451. eCollection 2018.

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