Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFC0072)
HIF Name	CD8+ HLADR+ T cells
HIF Synonym(s)	CD8+ HLADR+ T-cell, CD8+ HLADR+ T cells
HIF Classification	T cells (TCs)
Description	CD8 + HLA-DR + regulatory T cell subset with the ability to suppress proliferation of autologous PBMCs responder cells through cell contact and CTLA-4 co-inhibitory molecule.	[1]

Microbe Species (MIC) Regulated by This HIF
Subdoligranulum variabile (firmicutes)		MIC01286
Description	Subdoligranulum is positively correlated with CD8+ HLA-DR+ T-cell counts and percentages.		[2]

References
1	Human CD8(+)HLA-DR(+) Regulatory T Cells, Similarly to Classical CD4(+)Foxp3(+) Cells, Suppress Immune Responses via PD-1/PD-L1 Axis. Front Immunol. 2018 Nov 29;9:2788. doi: 10.3389/fimmu.2018.02788. eCollection 2018.
2	Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients. Front Microbiol. 2018 Jul 2;9:1451. doi: 10.3389/fmicb.2018.01451. eCollection 2018.

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