General Information of MIC (ID: MIC01911)
MIC Name	Coriobacteriaceae (actinobacteria)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Actinobacteria Class: Coriobacteriia Order: Coriobacteriales Family: Coriobacteriaceae
Description	Coriobacterineae is a suborder of the order Coriobacteriales.
External Links	Taxonomy ID	84107
	Genome Assembly ID	ASM479392v1
Disease Relevance
Inflammatory bowel disease  [ICD-11: DD72]
Description	The numbers of Coriobacteriaceae bacteria were low in inflammatory bowel disease patients.				[1]
Meningococcal disease  [ICD-11: 1C1C]
Description	Eggerthella lenta which belongs to the actinobacterial family Coriobacteriaceae can cause severe bacteremia.				[2]
Periodontal disease  [ICD-11: DA0C]
Description	Coriobacteriaceae was associated with periodontitis.				[3]

Host Genetic Factors (HGFs)
rs5030728
HGF ID	HGF1280	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The variant gene TLR4 of innate immunity rs5030728 is significantly associated with the abundance of gut micriobiota Coriobacteriaceae (p-value=0.0128).				[4]

Host Immune Factors (HIFs)
Immunoglobulin E
HIF ID	HIFM0271	HIF Info	Class	Immunoglobulin (Ig)
Description	IgE immune responses was associated with Coriobacteriaceae.				[5]

Environmental Factor(s)
Disbiome ID			242
gutMDisorder ID			gm0226

References
1	Altered Fecal Microbiota in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2015 Dec;9(12):1088-95. doi: 10.1093/ecco-jcc/jjv147. Epub 2015 Sep 7.
2	Complete genome sequence of Eggerthella lenta type strain (IPP VPI 0255). Stand Genomic Sci. 2009 Sep 28;1(2):174-82. doi: 10.4056/sigs.33592.
3	Characterization of novel human oral isolates and cloned 16S rDNA sequences that fall in the family Coriobacteriaceae: description of olsenella gen. nov., reclassification of Lactobacillus uli as Olsenella uli comb. nov. and description of Olsenella profusa sp. nov. Int J Syst Evol Microbiol. 2001 Sep;51(Pt 5):1797-1804. doi: 10.1099/00207713-51-5-1797.
4	Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
5	Microbiota and Derived Parameters in Fecal Samples of Infants with Non-IgE Cow's Milk Protein Allergy under a Restricted Diet.Nutrients. 2018 Oct 11;10(10):1481. doi: 10.3390/nu10101481.

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