Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00232)
MIC Name Bifidobacterium longum (actinobacteria)
MIC Synonyms Bifidobacterium sp. 12_1_47BFAA
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
Species: Bifidobacterium longum
Oxygen Sensitivity Obligate anaerobe; Microaerophilic
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Probiotic
Genome Size (bp) 2455762
No. of Coding Genes 1901
No. of Non-Coding Genes 65
No. of Small Non-Coding Genes 65
No. of Gene Transcripts 1966
No. of Base Pairs 2480603
Description Bifidobacterium longum is an obligately anaerobic, microaerophilic, Gram-positive, catalase-negative, rod-shaped bacterium present in the human gastrointestinal tract. It is a microaerotolerant anaerobe and considered to be one of the earliest colonizers of the gastrointestinal tract of infants.
External Links Taxonomy ID
216816
Genome Assembly ID
ASM73020v1
GOLD Organism ID
Go0117415
Disease Relevance
          Anxiety disorder  [ICD-11: 6B00]
             Description Bifidobacterium longum can ameliorate Anxiety. [1]
          Coeliac disease  [ICD-11: DA95]
             Description Coeliac disease was associated with Bifidobacterium longum infection. [2]
          Depression  [ICD-11: 6A70]
             Description Bifidobacterium longum can ameliorate Depression. [1]
          Post traumatic stress disorder  [ICD-11: 6B40]
             Description Bifidobacterium longum was associated with posttraumatic stress disorder. [1]
          Type 1 diabetes mellitus  [ICD-11: 5A10]
             Description Bifidobacterium longum was associated with type 1 diabetes. [3]
Host Genetic Factors (HGFs)
          rs651821
             HGF ID HGF1924 HGF Info       Class Single Nucleotide Polymorphism: Prime UTR variant (SNP-PV)
             Description The APOA5 SNP rs651821 might be an important host genetic factor in determining the abundances of the health-promoting Bifidobacterium bacteria and the taxa to which this genus belongs. [4]
          rs7097656
             HGF ID HGF2572 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7097656 SNP is associated with the abundance of Bifidobacterium longum. [5]
          rs3742130
             HGF ID HGF2570 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-SV)
             Description The rs3742130 SNP is associated with the abundance of Bifidobacterium longum. [5]
          rs12778642
             HGF ID HGF2566 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs12778642 SNP is associated with the abundance of Bifidobacterium longum. [5]
          rs7517810
             HGF ID HGF2531 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7517810 SNP is associated with the abundance of Bifidobacterium longum. [5]
          rs6088765
             HGF ID HGF2602 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6088765 SNP is associated with the abundance of Bifidobacterium longum. [5]
          rs11741861
             HGF ID HGF2619 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs11741861 SNP is associated with the abundance of Bifidobacterium longum. [5]
          rs10781499
             HGF ID HGF2620 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-SV)
             Description The rs10781499 SNP is associated with the abundance of Bifidobacterium longum. [5]
          rs17229285
             HGF ID HGF2578 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs17229285 SNP is associated with the abundance of Bifidobacterium longum. [5]
Host Immune Factors (HIFs)
          Programmed death-ligand 1
             HIF ID HIFM0189 HIF Info       Class Checkpoint molecule (CM)
             Description Bifidobacterium longum was associated with anti-tumor efficacies of PD-1-based therapy. [6]
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Bifidobacterium longum induced the highest IL-10 production by PBMC, showing significant differences in IL-10 production in the presence of Bifidobacterium infantis and the breast-fed mixture(p<0.05). [7]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Bifidobacterium longum stimulated PBMC to produce high levels of IL-6. [7]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Bifidobacterium longum is the highest inducer of IL-10 and the lowest TNF-Alpha stimulus. [7]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description Bifidobacterium longum could inhibite IFN-Gamma production. [7]
          Immunoglobulin E
             HIF ID HIFM0271 HIF Info       Class Immunoglobulin (Ig)
             Description The relative abundance of Bifidobacterium longum showed an inverse association with atopic sensitization, the number of allergen-specific IgEs and the development of allergy (p = 0.023, p = 0.026, p = 0.022). [8]
          Immunoglobulin A1
             HIF ID HIFM0275 HIF Info       Class Immunoglobulin (Ig)
             Description IgA1 has regulatory affinity which could bind to Bifidobacterium longum [9]
          Immunoglobulin A2
             HIF ID HIFM0276 HIF Info       Class Immunoglobulin (Ig)
             Description IgA2 has regulatory affinity which could bind to Bifidobacterium longum. [9]
Environmental Factor(s)
             Disbiome ID
      39
             gutMDisorder ID
      gm0112
References
1 Posttraumatic Stress Disorder: Does the Gut Microbiome Hold the Key. Can J Psychiatry. 2016 Apr;61(4):204-13. doi: 10.1177/0706743716635535. Epub 2016 Feb 24.
2 Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease. BMC Microbiol. 2008 Dec 22;8:232. doi: 10.1186/1471-2180-8-232.
3 The human gut microbiome in early-onset type 1 diabetes from the TEDDY study. Version 2. Nature. 2018 Oct;562(7728):589-594. doi: 10.1038/s41586-018-0620-2. Epub 2018 Oct 24.
4 The effect of heritability and host genetics on the gut microbiota and metabolic syndrome.Gut. 2017 Jun;66(6):1031-1038. doi: 10.1136/gutjnl-2015-311326. Epub 2016 Apr 6.
5 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
6 Microbial biomarkers for immune checkpoint blockade therapy against cancer.J Gastroenterol. 2018 Sep;53(9):999-1005. doi: 10.1007/s00535-018-1492-9. Epub 2018 Jul 12.
7 Immunostimulatory effect of faecal Bifidobacterium species of breast-fed and formula-fed infants in a peripheral blood mononuclear cell/Caco-2 co-culture system. Br J Nutr. 2011 Oct;106(8):1216-23. doi: 10.1017/S0007114511001656. Epub 2011 May 31.
8 Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life.Front Immunol. 2019 Oct 23;10:2494. doi: 10.3389/fimmu.2019.02494. eCollection 2019.
9 Human IgA binds a diverse array of commensal bacteria.J Exp Med. 2020 Mar 2;217(3):e20181635. doi: 10.1084/jem.20181635.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.