General Information of HIF (ID: HIFM0276)
HIF Name	Immunoglobulin A2
HIF Synonym(s)	IgA2
HIF Classification	Immunoglobulin (Ig)
Description	Immunoglobulin A2(IgA2) is a IgA subtype.It plays key roles in protecting the mucous membranes of the respiratory, gastrointestinal, and genitourinary tracts from attack by pathogenic microorganisms and their products.				[1]

Microbe Species (MIC) Regulated by This HIF
Bacteroides sp. (CFB bacteria)			MIC00176
Description	Bacteroides could be preferentially recognized by IgA2 in the stool samples.				[2]
Bacteroides vulgatus (CFB bacteria)			MIC00186
Description	Bacteroides vulgatus could be only recognized by IgA2.				[2]
Bifidobacterium longum (actinobacteria)			MIC00232
Description	IgA2 has regulatory affinity which could bind to Bifidobacterium longum.				[2]
Bifidobacterium sp. (actinobacteria)			MIC00224
Description	Bifidobacterium was coated by IgA2.				[2]
Candida albicans (budding yeasts)			MIC00317
Description	IgA2 level is significantly associated with the numbers of Candida organisms isolated from saliva.				[3]
Entamoeba histolytica (eukaryotes)			MIC00528
Description	Entamoeba histolytica trophozoites could degrade the level of human IgA2 and result in the low IgA2 concentration.				[4]
Porphyromonas gingivalis (CFB bacteria)			MIC01000
Description	The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin A2(lgA2).				[5]
Prevotella sp. (CFB bacteria)			MIC01024
Description	Prevotella could be preferentially recognized by IgA2 in the stool samples.				[2]
Serratia fonticola (enterobacteria)			MIC01169
Description	Serratia was coated by IgA2.				[2]
Staphylococcus haemolyticus (firmicutes)			MIC01215
Description	Staphylococcus haemolyticus could be recognized by IgA2.				[2]
Streptococcus pneumoniae (firmicutes)			MIC01263
Description	Streptococcus pneumoniae surface antigen could have higher proportion of IgA2.				[6]

References
1	Effect of mutations in the human immunoglobulin A1 (IgA1) hinge on its susceptibility to cleavage by diverse bacterial IgA1 proteases.Infect Immun. 2005 Mar;73(3):1515-22. doi: 10.1128/IAI.73.3.1515-1522.2005.
2	Human IgA binds a diverse array of commensal bacteria.J Exp Med. 2020 Mar 2;217(3):e20181635. doi: 10.1084/jem.20181635.
3	Immunoglobulin A (IgA), IgA1, and IgA2 antibodies to Candida albicans in whole and parotid saliva in human immunodeficiency virus infection and AIDS.Infect Immun. 1994 Mar;62(3):892-6. doi: 10.1128/IAI.62.3.892-896.1994.
4	Degradation of human secretory IgA1 and IgA2 by Entamoeba histolytica surface-associated proteolytic activity.Parasitol Int. 2008 Dec;57(4):417-23. doi: 10.1016/j.parint.2008.04.013. Epub 2008 May 15.
5	Immunoglobulin-degrading enzymes in localized juvenile periodontitis.J Periodontal Res. 1992 May;27(3):176-83. doi: 10.1111/j.1600-0765.1992.tb01666.x.
6	Subclass distribution of natural salivary IgA antibodies against pneumococcal capsular polysaccharide of type 14 and pneumococcal surface adhesin A (PsaA) in children.Clin Exp Immunol. 2006 Mar;143(3):543-9. doi: 10.1111/j.1365-2249.2006.03009.x.

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