Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00186)
MIC Name Bacteroides vulgatus (CFB bacteria)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides vulgatus
Oxygen Sensitivity Anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Commensal
Genome Size (bp) 5165891
No. of Coding Genes 4233
No. of Non-Coding Genes 100
No. of Small Non-Coding Genes 100
No. of Gene Transcripts 4333
No. of Base Pairs 5165891
Description Bacteroides vulgatus is an anaerobic, Gram negative among the most commonly isolated microbes from the human gastrointestinal tract, and it has been found to constitute part of the core gut microbiota in healthy humans. It is generally considered to be a beneficial gut commensal, but studies also suggest that important intraspecies variations may exist, with specific strains of B. vulgatus shown to be capable of promoting or protecting against colitis.
External Links Taxonomy ID
821
Genome Assembly ID
ASM141231v1
GOLD Organism ID
Go0487063
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description A lower abundance of Bacteroides vulgatus showed in children with autism spectrum disorder. [1]
          Coeliac disease  [ICD-11: DA95]
             Description Bacteroides vulgatus were detected more often in Celiac disease patients than in controls. [2]
          Crohn disease  [ICD-11: DD70]
             Description Bacteroides vulgatus enriched in Crohns disease patients [3]
          Diseases of coronary artery  [ICD-11: BA8Z]
             Description Fecal lipopolysaccharide levels in patients with Coronary artery disease were significantly higher and negatively correlated with the abundance of Bacteroides vulgatus. [4]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description The suppressive effect of bifidobacteria on Bacteroides vulgatus, a putative pathogenic microbe in inflammatory bowel disease. [5]
          Ulcerative colitis  [ICD-11: DD71]
             Description Ulcerative colitis was associated with Bacteroides vulgatus infection. [6]
Host Genetic Factors (HGFs)
          CD44
             HGF ID HGF2333 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of CD44 significantly decreased the abundance of Bacteroides vulgatus (p-value<0.05). [7]
          rs34133517
             HGF ID HGF2050 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs34133517 SNP was significantly associated with the abundance of Bacteroides vulgatus (p-value<1.00E-08). [8]
Host Immune Factors (HIFs)
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Bacteroides vulgatus was selectively IgA+(High IgA binding) coated in patients with inflammatory bowel disease(Crohn disease and ulcerative colitis). [9]
          Immunoglobulin A2
             HIF ID HIFM0276 HIF Info       Class Immunoglobulin (Ig)
             Description Bacteroides vulgatus could be only recognized by IgA2. [10]
Environmental Factor(s)
             Disbiome ID
      61
             gutMDisorder ID
      gm0089
References
1 Alterations in Gut Glutamate Metabolism Associated with Changes in Gut Microbiota Composition in Children with Autism Spectrum Disorder. mSystems. 2019 Jan 29;4(1):e00321-18. doi: 10.1128/mSystems.00321-18. eCollection 2019 Jan-Feb.
2 A distinctive 'microbial signature' in celiac pediatric patients. BMC Microbiol. 2010 Jun 17;10:175. doi: 10.1186/1471-2180-10-175.
3 Influences of intestinal bacteria in human inflammatory bowel disease. Infect Dis Clin North Am. 2010 Dec;24(4):977-93, ix. doi: 10.1016/j.idc.2010.07.008.
4 Bacteroides vulgatus and Bacteroides dorei Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis. Circulation. 2018 Nov 27;138(22):2486-2498. doi: 10.1161/CIRCULATIONAHA.118.033714.
5 The suppressive effect of bifidobacteria on Bacteroides vulgatus, a putative pathogenic microbe in inflammatory bowel disease. Microbiol Immunol. 2003;47(6):371-8. doi: 10.1111/j.1348-0421.2003.tb03368.x.
6 Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota. BMC Gastroenterol. 2010 Nov 12;10:134. doi: 10.1186/1471-230X-10-134.
7 CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice.Eur J Immunol. 2017 Jul;47(7):1188-1199. doi: 10.1002/eji.201646792. Epub 2017 Jun 6.
8 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
9 IgA Function in Relation to the Intestinal Microbiota.Annu Rev Immunol. 2018 Apr 26;36:359-381. doi: 10.1146/annurev-immunol-042617-053238. Epub 2018 Jan 26.
10 Human IgA binds a diverse array of commensal bacteria.J Exp Med. 2020 Mar 2;217(3):e20181635. doi: 10.1084/jem.20181635.

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