Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01024)
MIC Name Prevotella sp. (CFB bacteria)
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Prevotella
Species: Prevotella sp.
Oxygen Sensitivity Anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Description Prevotella sp. is an anaerobic, Gram negative species. It was isolated from a population of Prevotella which are clearly distinct from currently recognized species are tentatively designated at the species level.
External Links Taxonomy ID
59823
GOLD Organism ID
Go0005189
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Prevotella was associated with autism. [1]
          Parkinsonism  [ICD-11: 8A00]
             Description A decrease of Prevotella spp. was observed in Parkinsons disease. [2]
          Spondyloarthritis  [ICD-11: FA92]
             Description The ankylosing spondylitis patients demonstrated increases in the abundance of Prevotella sp. C561. [3]
          Type 2 diabetes mellitus  [ICD-11: 5A11]
             Description Bacteroides-Prevotella is upregulated in disease expression of Type 2 diabetes. [4]
Host Genetic Factors (HGFs)
          15q11-13
             HGF ID HGF2318 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description Prevotella sp. was less abundant in 15q dup control mice than in wide type control (p-value<0.05). [5]
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The relative abundance of Prevotella, was twofold higher in adults with a high number of AMY1 copies (10) as compared to those with a low AMY1 copy number (4). [6]
          ARNTL
             HGF ID HGF2325 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of BMAL1 could decrease relative abundances of Prevotella (p-value<0.01). [7]
          MIR21
             HGF ID HGF2332 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of MIR-21 was significantly reduced the proportion of Prevotella (p-value<0.05). [8]
          SLC15A1
             HGF ID HGF2354 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of PepT1 could increase the abundance of Prevotella. [9]
          NLRP3
             HGF ID HGF2355 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of NLRP3 could significantly increase the abundance of Prevotella (p-value<0.001). [10]
          rs8019270
             HGF ID HGF1297 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs8019270 SNP was significantly associated with the abundance of Prevotella (p-value=5.84E-06). [11]
          rs61729490
             HGF ID HGF1762 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs61729490 SNP was significantly associated with the abundance of Prevotella (p-value=7.07E-05). [12]
          rs56407805
             HGF ID HGF1763 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The rs56407805 SNP was significantly associated with the abundance of Prevotella (p-value=2.92E-06). [11]
          rs4986790
             HGF ID HGF1279 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The variant in TLR4 rs4986790 was associated with an increase in Prevotella. [13]
          rs4968839
             HGF ID HGF1952 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs4968839 SNP was significantly associated with the abundance of Prevotella (p-value=3.37E-07). [11]
          rs1966834
             HGF ID HGF1447 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs1966834 SNP was significantly associated with the abundance of Prevotella (p-value=4.52E-06). [11]
          rs1110168
             HGF ID HGF1409 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs1110168 SNP was significantly associated with the abundance of Prevotella (p-value=6.92E-06). [11]
          rs11077414
             HGF ID HGF1954 HGF Info       Class Single Nucleotide Polymorphism: Stop gained (SNP-SG)
             Description The rs11077414 SNP was significantly associated with the abundance of Prevotella (p-value=9.99E-07). [11]
Host Immune Factors (HIFs)
          C-C motif chemokine 13
             HIF ID HIFM0018 HIF Info       Class Antimicrobial peptide (AMP)
             Description Patients with a Prevotella-rich gut enterotype displayed increased serum levels of the chemokines CCL13. [14]
          C-C motif chemokine 17
             HIF ID HIFM0019 HIF Info       Class Antimicrobial peptide (AMP)
             Description Patients with a Prevotella-rich gut enterotype displayed increased serum levels of the chemokines CCL17. [14]
          C-C motif chemokine 22
             HIF ID HIFM0025 HIF Info       Class Antimicrobial peptide (AMP)
             Description Patients with a Prevotella-rich gut enterotype displayed increased serum levels of the chemokines CCL22. [14]
          B cells
             HIF ID HIFC0001 HIF Info       Class B cells (BCs)
             Description Relative abundances of Prevotella is associated with B cells response. [15]
          CD20+ B cells
             HIF ID HIFC0137 HIF Info       Class B cells (BCs)
             Description Prevotella was negatively correlated with CD20+ B cell in the liver lobule. [16]
          CD40 ligand
             HIF ID HIFM0051 HIF Info       Class Checkpoint molecule (CM)
             Description T helper cells up-regulates CD154 when stimulated with antigens from Prevotella. [17]
          Programmed Cell Death 1 Protein
             HIF ID HIFM0191 HIF Info       Class Checkpoint molecule (CM)
             Description The relative abudance of the Prevotella sp.is effected by PD-1 antibody treatment. [18]
          Programmed death-ligand 1
             HIF ID HIFM0189 HIF Info       Class Checkpoint molecule (CM)
             Description Prevotella is associated with PD-L1. [19]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description Prevotella positively correlate with IgM in patients with Henoch-Schnlein Purpura. [20]
          Immunoglobulin A2
             HIF ID HIFM0276 HIF Info       Class Immunoglobulin (Ig)
             Description Prevotella could be preferentially recognized by IgA2 in the stool samples. [21]
          CD16+ Natural Killer cells
             HIF ID HIFC0094 HIF Info       Class Natural killer cells (NKCs)
             Description The increased proportion of CD16+ NK cells was associated with the decrease of gut commensal bacteria(Prevotella). [22]
          T-cell surface glycoprotein CD4
             HIF ID HIFM0050 HIF Info       Class T-cell receptor (TCR)
             Description The stool of HIV-infected patients with high CD4 counts were enriched for traditional gastrointestinal genera Prevotella(false discovery rate q < 0.05, read difference 100 reads, and presence in 50%). [23]
Environmental Factor(s)
             Disbiome ID
      44
             gutMDisorder ID
      gm0535
References
1 Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders. Anaerobe. 2018 Feb;49:121-131. doi: 10.1016/j.anaerobe.2017.12.007. Epub 2017 Dec 22.
2 Changes of Colonic Bacterial Composition in Parkinson's Disease and Other Neurodegenerative Diseases. Nutrients. 2018 Jun 1;10(6):708. doi: 10.3390/nu10060708.
3 Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis. Genome Biol. 2017 Jul 27;18(1):142. doi: 10.1186/s13059-017-1271-6.
4 The impact of the gut microbiota on human health: an integrative view. Cell. 2012 Mar 16;148(6):1258-70. doi: 10.1016/j.cell.2012.01.035.
5 Altered microbiota composition reflects enhanced communication in 15q11-13 CNV mice.Neurosci Res. 2019 Dec 18:S0168-0102(19)30671-6. doi: 10.1016/j.neures.2019.12.010. Online ahead of print.
6 Low Salivary Amylase Gene (AMY1) Copy Number Is Associated with Obesity and Gut Prevotella Abundance in Mexican Children and Adults.Nutrients. 2018 Nov 1;10(11):1607. doi: 10.3390/nu10111607.
7 Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock.Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10479-84. doi: 10.1073/pnas.1501305112. Epub 2015 Aug 3.
8 Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis.J Crohns Colitis. 2018 Jun 28;12(7):835-848. doi: 10.1093/ecco-jcc/jjy038.
9 Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.NPJ Biofilms Microbiomes. 2020 Jul 21;6(1):27. doi: 10.1038/s41522-020-0137-y.
10 Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2.Microbiome. 2019 Aug 22;7(1):116. doi: 10.1186/s40168-019-0733-3.
11 Host genetic variation impacts microbiome composition across human body sites.Genome Biol. 2015 Sep 15;16(1):191. doi: 10.1186/s13059-015-0759-1.
12 Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.Gut. 2020 Jul 10:gutjnl-2019-319706. doi: 10.1136/gutjnl-2019-319706. Online ahead of print.
13 Genetic association of Toll-like receptor 4 with cervical cytokine concentrations during pregnancy.Genes Immun. 2009 Oct;10(7):636-40. doi: 10.1038/gene.2009.47. Epub 2009 Jun 25.
14 Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients.Nat Commun. 2019 Dec 13;10(1):5711. doi: 10.1038/s41467-019-13751-9.
15 Microbiota-Propelled T Helper 17 Cells in Inflammatory Diseases and Cancer. Microbiol Mol Biol Rev. 2020 Mar 4;84(2):e00064-19. doi: 10.1128/MMBR.00064-19. Print 2020 May 20.
16 Markers of activated inflammatory cells are associated with disease severity and intestinal microbiota inadults with nonalcoholic fatty liver disease.Int J Mol Med. 2018 Oct;42(4):2229-2237. doi: 10.3892/ijmm.2018.3800. Epub 2018 Aug 2.
17 Inflammatory Bowel Disease Types Differ in Markers of Inflammation, Gut Barrier and in Specific Anti-Bacterial Response.Cells. 2019 Jul 13;8(7):719. doi: 10.3390/cells8070719.
18 Gut Microbiome Influences the Efficacy of PD-1 Antibody Immunotherapy on MSS-Type Colorectal Cancer via Metabolic Pathway.Front Microbiol. 2020 Apr 30;11:814. doi: 10.3389/fmicb.2020.00814. eCollection 2020.
19 Modulation of gut microbiota to overcome resistance to immune checkpoint blockade in cancer immunotherapy.Curr Opin Pharmacol. 2020 Jun 30;54:1-10. doi: 10.1016/j.coph.2020.06.004. Online ahead of print.
20 Oral microbiota dysbiosis and its association with Henoch-Schnlein Purpura in children.Int Immunopharmacol. 2018 Dec;65:295-302. doi: 10.1016/j.intimp.2018.10.017. Epub 2018 Oct 17.
21 Human IgA binds a diverse array of commensal bacteria.J Exp Med. 2020 Mar 2;217(3):e20181635. doi: 10.1084/jem.20181635.
22 Dysbiosis of gut microbiome affecting small intestine morphology and immune balance: a rhesus macaque model.Zool Res. 2020 Jan 18;41(1):20-31. doi: 10.24272/j.issn.2095-8137.2020.004.
23 Gut microbiota in HIV-pneumonia patients is related to peripheral CD4 counts, lung microbiota, and in vitro macrophage dysfunction. Microbiome. 2019 Mar 11;7(1):37. doi: 10.1186/s40168-019-0651-4.

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