Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0051)
HIF Name
CD40 ligand
HIF Synonym(s)
CD40-L, TRAP, T-cell antigen Gp39, CD154, CD40L
HIF Classification
Checkpoint molecule (CM)
Molecular Function
Cytokine
Description CD40 ligand is a key mediator of inflammation. It confers a proinflammatory phenotype to macrophages and controls several macrophagic functions. [1]
Pfam TNF(Tumour Necrosis Factor) family (PF00229 )
Pathway Allograft rejection (hsa05330 )
Asthma (hsa05310 )
Autoimmune thyroid disease (hsa05320 )
Cell adhesion molecules (CAMs) (hsa04514 )
Cytokine-cytokine receptor interaction (hsa04060 )
Intestinal immune network for IgA production (hsa04672 )
Malaria (hsa05144 )
NF-kappa B signaling pathway (hsa04064 )
Primary immunodeficiency (hsa05340 )
Systemic lupus erythematosus (hsa05322 )
T cell receptor signaling pathway (hsa04660 )
Toxoplasmosis (hsa05145 )
Viral myocarditis (hsa05416 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CD40L_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Blautia producta (firmicutes) MIC00981
             Description T helper cells up-regulates CD154 when stimulated with antigens from Blautia. [2]
         Escherichia coli (enterobacteria) MIC00516
             Description T helper cells up-regulates CD40L (CD154) when stimulated with antigens from Escherichia coli. [2]
         Lactobacillus sp. (firmicutes) MIC00701
             Description T helper cells up-regulates CD154 when stimulated with antigens from Lactobacillus. [2]
         Prevotella sp. (CFB bacteria) MIC01024
             Description T helper cells up-regulates CD154 when stimulated with antigens from Prevotella. [2]
         Roseburia sp. (firmicutes) MIC01115
             Description T helper cells up-regulates CD154 when stimulated with antigens from Roseburia. [2]
         Streptococcus sanguinis (firmicutes) MIC01269
             Description Streptococcus sanguinis 201778 stimulated the release of significant amounts of sCD40L from platelets(p<0.05). [3]
References
1 A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation.Mediators Inflamm. 2017;2017:2982879. doi: 10.1155/2017/2982879. Epub 2017 Jul 12.
2 Inflammatory Bowel Disease Types Differ in Markers of Inflammation, Gut Barrier and in Specific Anti-Bacterial Response.Cells. 2019 Jul 13;8(7):719. doi: 10.3390/cells8070719.
3 Streptococcus sanguinis-induced cytokine and matrix metalloproteinase-1 release from platelets. BMC Immunol. 2014 Apr 22;15:15. doi: 10.1186/1471-2172-15-15.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.