Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00981)
MIC Name Blautia producta (firmicutes)
MIC Synonyms Streptococcus productus
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Blautia
Species: Blautia producta
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative; Hydrogen used as energy source
Gram Positive
Host Relationship Commensal
Genome Size (bp) 6085111
Description Blautia producta is an obligate anaerobic, Gram positive species. Decrease of this bacterium is known to associated with Ulcerative colitis (UC) development.
External Links Taxonomy ID
33035
Genome Assembly ID
ASM421025v1
GOLD Organism ID
Go0518835
Disease Relevance
          Depression  [ICD-11: 6A70]
             Description Blautia was identified by more than one report as elevated in major depressive disorder. [1]
          Ulcerative colitis  [ICD-11: DD71]
             Description Decrease of Peptostreptococcus productus in the intestinal tract may translate into a reduction in the important role of this beneficial bacterial species, which can lead to reduced protection of the gut mucosa and ulcerative colitis development. [2]
Host Genetic Factors (HGFs)
          FPR2
             HGF ID HGF2316 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The gene FPR2 with exon duplications was significantly associated with decreased abundance of Blautia. [3]
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description Gut microbiome Blautia differs between high AMY1-CN and low AMY1-CN groups at the OTU Level (p-value<0.05). [4]
          rs79387448
             HGF ID HGF2144 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs79387448 SNP was significantly associated with the abundance of Blautia (p-value=7.68E-11). [5]
          rs6929224
             HGF ID HGF2029 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6929224 SNP was significantly associated with the abundance of Blautia (p-value=4.28E-07). [6]
          rs6591450
             HGF ID HGF1577 HGF Info       Class Single Nucleotide Polymorphism: Non coding transcript variant (SNP-NCTV)
             Description The rs6591450 SNP was significantly associated with the abundance of Blautia (p-value=2.25E-07). [6]
          rs4673912
             HGF ID HGF1325 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The rs4673912 SNP was significantly associated with the abundance of Blautia (p-value=8.34E-07). [6]
          rs4669413
             HGF ID HGF2107 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs4669413 SNP was significantly associated with the abundance of Blautia (p-value=1.20E-8). [5]
          rs2075820
             HGF ID HGF1458 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The variant gene NOD1 of innate immunity rs2075820 is significantly associated with the abundance of gut micriobiota Blautia (p-value=0.0181). [7]
          rs1986785
             HGF ID HGF1498 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1986785 SNP was significantly associated with the abundance of Blautia (p-value=1.30E-07). [6]
          rs17862118
             HGF ID HGF1309 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs17862118 SNP was significantly associated with the abundance of Blautia (p-value=2.40E-07). [6]
          rs17585587
             HGF ID HGF1765 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs17585587 SNP was significantly associated with the abundance of Blautia (p-value=1.49E-06). [6]
Host Immune Factors (HIFs)
          CD40 ligand
             HIF ID HIFM0051 HIF Info       Class Checkpoint molecule (CM)
             Description T helper cells up-regulates CD154 when stimulated with antigens from Blautia. [8]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Blautia spp. at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease. [9]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Peptostreptococcus productus is associated with IgM response. [10]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Peptostreptococcus productus is associated with IgM response. [10]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Blautia was selectively IgA+(High IgA binding) coated in patients with inflammatory bowel disease(Crohn disease and ulcerative colitis). [11]
          Immunoglobulin E
             HIF ID HIFM0271 HIF Info       Class Immunoglobulin (Ig)
             Description Blautia resulted increased in non-IgE-mediated CMA(cows milk allergy) patients. [12]
Environmental Factor(s)
             Disbiome ID
      1387
             gutMDisorder ID
      gm0117
References
1 Systematic Review of Gut Microbiota and Major Depression. Front Psychiatry. 2019 Feb 11;10:34. doi: 10.3389/fpsyt.2019.00034. eCollection 2019.
2 Longitudinal Analyses of Gut-Associated Bacterial Microbiota in Ulcerative Colitis Patients. Arch Iran Med. 2018 Dec 1;21(12):578-584.
3 Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.Gut. 2020 Jul 10:gutjnl-2019-319706. doi: 10.1136/gutjnl-2019-319706. Online ahead of print.
4 Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.Cell Host Microbe. 2019 Apr 10;25(4):553-564.e7. doi: 10.1016/j.chom.2019.03.001.
5 Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.Nat Genet. 2016 Nov;48(11):1396-1406. doi: 10.1038/ng.3695. Epub 2016 Oct 10.
6 Genetic Determinants of the Gut Microbiome in UK Twins.Cell Host Microbe. 2016 May 11;19(5):731-43. doi: 10.1016/j.chom.2016.04.017.
7 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
8 Inflammatory Bowel Disease Types Differ in Markers of Inflammation, Gut Barrier and in Specific Anti-Bacterial Response.Cells. 2019 Jul 13;8(7):719. doi: 10.3390/cells8070719.
9 Stool Microbiota at Neutrophil Recovery Is Predictive for Severe Acute Graft vs Host Disease After Hematopoietic Cell Transplantation.Clin Infect Dis. 2017 Nov 29;65(12):1984-1991. doi: 10.1093/cid/cix699.
10 Serum agglutinins to Eubacterium and Peptostreptococcus species in Crohn's and other diseases. J Hyg (Lond). 1981 Aug;87(1):13-24. doi: 10.1017/s0022172400069199.
11 IgA Function in Relation to the Intestinal Microbiota.Annu Rev Immunol. 2018 Apr 26;36:359-381. doi: 10.1146/annurev-immunol-042617-053238. Epub 2018 Jan 26.
12 Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow's milk allergy.Sci Rep. 2018 Aug 21;8(1):12500. doi: 10.1038/s41598-018-30428-3.

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