Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01269)
MIC Name Streptococcus sanguinis (firmicutes)
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus sanguinis
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Genome Size (bp) 2388435
No. of Coding Genes 2193
No. of Non-Coding Genes 64
No. of Small Non-Coding Genes 64
No. of Gene Transcripts 2294
No. of Pseudogenes 37
No. of Base Pairs 2308610
Description Streptococcus sanguinis formerly known as Streptococcus sanguis, is a Gram-positive facultative anaerobic coccus species of bacteria and a member of the Viridans Streptococcus group. S. sanguinis is a normal inhabitant of the healthy human mouth where it is particularly found in dental plaque.
External Links Taxonomy ID
1305
Genome Assembly ID
Streptococcus_sanguinis_2908
GOLD Organism ID
Go0005562
Disease Relevance
          Infectious endocarditis  [ICD-11: BB40]
             Description Streptococcus sanguinis was associated with infective endocarditis. [1]
Host Genetic Factors (HGFs)
          rs6809053
             HGF ID HGF2091 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6809053 SNP was significantly associated with the abundance of Streptococcus sanguinis (p-value<1.00E-08). [2]
          rs4798206
             HGF ID HGF1822 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4798206 SNP was significantly associated with the abundance of Streptococcus sanguinis (p-value<1.00E-08). [2]
Host Immune Factors (HIFs)
          CD40 ligand
             HIF ID HIFM0051 HIF Info       Class Checkpoint molecule (CM)
             Description Streptococcus sanguinis 201778 stimulated the release of significant amounts of sCD40L from platelets(p<0.05). [3]
          C-X-C Motif Chemokine Ligand 12
             HIF ID HIFM0207 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus sanguinis stimulates the release of pro-inflammatory mediator SDF-1. [3]
          Immunoglobulin A1
             HIF ID HIFM0275 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of IgA1 proteases from Streptococcus sanguis could effect enzymolysis of human immunoglobulin A1(lgA1). [4]
Environmental Factor(s)
             Disbiome ID
      226
             gutMDisorder ID
      gm0624
             aBiofilm Organism
      Streptococcus sanguinis
References
1 HANDOC: A Handy Score to Determine the Need for Echocardiography in Non--Hemolytic Streptococcal Bacteremia. Clin Infect Dis. 2018 Feb 10;66(5):693-698. doi: 10.1093/cid/cix880.
2 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
3 Streptococcus sanguinis-induced cytokine and matrix metalloproteinase-1 release from platelets. BMC Immunol. 2014 Apr 22;15:15. doi: 10.1186/1471-2172-15-15.
4 Effect of mutations in the human immunoglobulin A1 (IgA1) hinge on its susceptibility to cleavage by diverse bacterial IgA1 proteases.Infect Immun. 2005 Mar;73(3):1515-22. doi: 10.1128/IAI.73.3.1515-1522.2005.

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