General Information of HIF (ID: HIFM0207)
HIF Name	C-X-C Motif Chemokine Ligand 12
HIF Synonym(s)	sdf1, Stromal cell-derived factor 1
HIF Classification	Cytokine (Cyt)
Molecular Function	Cytokine; Growth factor
Description	Cytokines induce release of SDF-1 from platelets. Hematopoietic and endothelial cells produce and store SDF-1 , suggesting that cytokines may stimulate release of SDF-1 from the hematopoietic compartment.				[1]
Pfam	Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway	Axon guidance (hsa04360 )
	Chemokine signaling pathway (hsa04062 )
	Cytokine-cytokine receptor interaction (hsa04060 )
	Human cytomegalovirus infection (hsa05163 )
	Intestinal immune network for IgA production (hsa04672 )
	Leukocyte transendothelial migration (hsa04670 )
	NF-kappa B signaling pathway (hsa04064 )
	Pathways in cancer (hsa05200 )
	Regulation of actin cytoskeleton (hsa04810 )
	Rheumatoid arthritis (hsa05323 )
	Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	SDF1_HUMAN

Microbe Species (MIC) Regulated by This HIF
Porphyromonas gingivalis (CFB bacteria)			MIC01000
Description	Porphyromonas gingivalis infection decrease the CXCL12 expression in gingival fibroblasts.				[2]
Streptococcus sanguinis (firmicutes)			MIC01269
Description	Streptococcus sanguinis stimulates the release of pro-inflammatory mediator SDF-1.				[3]

References
1	Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat Med. 2006 May;12(5):557-67. doi: 10.1038/nm1400. Epub 2006 Apr 30.
2	In vitro regulation of CCL3 and CXCL12 by bacterial by-products is dependent on site of origin of human oral fibroblasts.J Endod. 2014 Jan;40(1):95-100. doi: 10.1016/j.joen.2013.09.031. Epub 2013 Oct 27.
3	Streptococcus sanguinis-induced cytokine and matrix metalloproteinase-1 release from platelets. BMC Immunol. 2014 Apr 22;15:15. doi: 10.1186/1471-2172-15-15.

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