Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01115)
MIC Name Roseburia sp. (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Roseburia
Species: Roseburia sp.
Gram Positive
Description Roseburia is a member of the phylum firmicutes and a Gram-positive anaerobic bacterium that inhabits the human colon.
External Links Taxonomy ID
2049040
GOLD Organism ID
Go0546891
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Roseburia spp. was significantly elevated in autistic children. [1]
          Autoimmune liver disease  [ICD-11: DB96]
             Description Roseburia was associated with primary sclerosing cholangitis. [2]
          Chronic kidney disease  [ICD-11: GB61]
             Description Roseburia was negatively correlated with CKD(Chronic kidney disease) severity. [3]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description A decrease of Roseburia was observed in patients with Inflammatory bowel disease. [4]
          Ulcerative colitis  [ICD-11: DD71]
             Description Roseburia was associated with ulcerative colitis. [2]
Host Genetic Factors (HGFs)
          rs9397979
             HGF ID HGF1919 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs9397979 SNP is significantly associated with the abundance of gut microbiota Roseburia (p-value<5.00E-05). [5]
          rs7231241
             HGF ID HGF2152 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7231241 SNP is significantly associated with the abundance of gut microbiota Roseburia (p-value<5.00E-05). [5]
          rs2832648
             HGF ID HGF2101 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs2832648 SNP is significantly associated with the abundance of gut microbiota Roseburia (p-value<5.00E-05). [5]
          rs194522
             HGF ID HGF1310 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs194522 SNP is significantly associated with the abundance of gut microbiota Roseburia (p-value<5.00E-05). [5]
          rs12128018
             HGF ID HGF1584 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12128018 SNP is significantly associated with the abundance of gut microbiota Roseburia (p-value<5.00E-05). [5]
          rs10058249
             HGF ID HGF1778 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10058249 SNP was significantly associated with the relative abundance of Roseburia (p-value=3.65E-09). [6]
          rs10486483
             HGF ID HGF2543 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10486483 SNP is associated with the abundance of Roseburia. [7]
          rs38911
             HGF ID HGF2577 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs38911 SNP is associated with the abundance of Roseburia. [7]
          rs6740462
             HGF ID HGF2537 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6740462 SNP is associated with the abundance of Roseburia. [7]
          rs17229285
             HGF ID HGF2578 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs17229285 SNP is associated with the abundance of Roseburia. [7]
          rs9264942
             HGF ID HGF2579 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs9264942 SNP is associated with the abundance of Roseburia. [7]
          rs6708413
             HGF ID HGF2544 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6708413 SNP is associated with the abundance of Roseburia. [7]
          rs9358372
             HGF ID HGF2580 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs9358372 SNP is associated with the abundance of Roseburia. [7]
          rs3774937
             HGF ID HGF2581 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs3774937 SNP is associated with the abundance of Roseburia. [7]
          rs32690134
             HGF ID HGF2582 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs32690134 SNP is associated with the heritable variation in Roseburia abundance. [8]
          rs27619452
             HGF ID HGF2583 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs27619452 SNP is associated with the heritable variation in Roseburia abundance. [8]
          rs3685172
             HGF ID HGF2584 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs3685172 SNP is associated with the heritable variation in Roseburia abundance. [8]
Host Immune Factors (HIFs)
          CD40 ligand
             HIF ID HIFM0051 HIF Info       Class Checkpoint molecule (CM)
             Description T helper cells up-regulates CD154 when stimulated with antigens from Roseburia. [9]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Roseburia was selectively IgA+ (High IgA binding) coated in patients with inflammatory bowel disease (Crohn disease and ulcerative colitis). [10]
          Regulatory T cells
             HIF ID HIFC0030 HIF Info       Class T cells (TCs)
             Description Roseburia is known to produce short chain fatty acids, which in their turn are known to induce Tregs(Regulatory cells). [11]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Roseburia could induce CD4+ cells responses. [11]
          CD8+ T cells
             HIF ID HIFC0073 HIF Info       Class T cells (TCs)
             Description Roseburia was associated with CD80+ T cells responses. [11]
Environmental Factor(s)
             Disbiome ID
      14
             gutMDisorder ID
      gm0571
References
1 The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder. Int J Mol Sci. 2019 Apr 29;20(9):2115. doi: 10.3390/ijms20092115.
2 Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol. 2017 Jul 7;23(25):4548-4558. doi: 10.3748/wjg.v23.i25.4548.
3 Gut Microbiota as Diagnostic Tools for Mirroring Disease Progression and Circulating Nephrotoxin Levels in Chronic Kidney Disease: Discovery and Validation Study. Int J Biol Sci. 2020 Jan 1;16(3):420-434. doi: 10.7150/ijbs.37421. eCollection 2020.
4 Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease. Gut. 2018 Jan;67(1):108-119. doi: 10.1136/gutjnl-2016-312135. Epub 2016 Oct 8.
5 Assessing the Relationship Between Gut Microbiota and Bone Mineral Density.Front Genet. 2020 Jan 31;11:6. doi: 10.3389/fgene.2020.00006. eCollection 2020.
6 Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
7 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
8 Complex host genetics influence the microbiome in inflammatory bowel disease. Genome Med. 2014 Dec 2;6(12):107. doi: 10.1186/s13073-014-0107-1. eCollection 2014.
9 Inflammatory Bowel Disease Types Differ in Markers of Inflammation, Gut Barrier and in Specific Anti-Bacterial Response.Cells. 2019 Jul 13;8(7):719. doi: 10.3390/cells8070719.
10 IgA Function in Relation to the Intestinal Microbiota.Annu Rev Immunol. 2018 Apr 26;36:359-381. doi: 10.1146/annurev-immunol-042617-053238. Epub 2018 Jan 26.
11 Microbiota Induced Changes in the Immune Response in Pregnant Mice. Front Immunol. 2020 Jan 9;10:2976. doi: 10.3389/fimmu.2019.02976. eCollection 2019.

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