General Information of HIF (ID: HIFM0018)
HIF Name	C-C motif chemokine 13
HIF Synonym(s)	Ccl13, MCP-4, CK-beta-10, NCC-1
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Cytokine
Description	CCL13 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Pfam	Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway	Chemokine signaling pathway (hsa04062 )
	Cytokine-cytokine receptor interaction (hsa04060 )
	NF-kappa B signaling pathway (hsa04064 )
	Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	CCL13_HUMAN
	APD ID	AP02092

Microbe Species (MIC) Regulated by This HIF
Atopobium vaginae (actinobacteria)			MIC00110
Description	The CCL13 significantly altered by co-culture with Atopobium and Porphyromonas.				[2]
Bacteroides sp. (CFB bacteria)			MIC00176
Description	The order of Bacteroidales abundance was correlated with expression of CCL13.				[3]
Bacteroides uniformis (CFB bacteria)			MIC00184
Description	Bacteroidetes in particular the class of Bacteroidia was correlated with expression of CCL13.				[3]
Bacteroidetes (CFB bacteria)			MIC00141
Description	The Bacteroidetes abundance was correlated with expression of CCL13.				[3]
Gemella haemolysans (firmicutes)			MIC00628
Description	The CCL13 expressionb was correlated only with the abundance of Gemellaceae.				[3]
Lactobacillus sp. (firmicutes)			MIC00701
Description	The CCL13 expression was upregulated by Lactobacillus.				[2]
Porphyromonas sp. (CFB bacteria)			MIC01003
Description	CCL13 significantly altered by co-culture with Atopobium and Porphyromonas.				[2]
Prevotella sp. (CFB bacteria)			MIC01024
Description	Patients with a Prevotella-rich gut enterotype displayed increased serum levels of the chemokines CCL13.				[4]
Proteobacteria (proteobacteria)			MIC01037
Description	The phylum Proteobacteria was correlated with the expression of CCL13.				[3]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Atopobium vaginae And Porphyromonas somerae Induce Proinflammatory Cytokines Expression In Endometrial Cells: A Possible Implication For Endometrial Cancer. Cancer Manag Res. 2019 Sep 23;11:8571-8575. doi: 10.2147/CMAR.S217362. eCollection 2019.
3	Duodenal Mucosa of Patients With Type 1 Diabetes Shows Distinctive Inflammatory Profile and Microbiota.J Clin Endocrinol Metab. 2017 May 1;102(5):1468-1477. doi: 10.1210/jc.2016-3222.
4	Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients.Nat Commun. 2019 Dec 13;10(1):5711. doi: 10.1038/s41467-019-13751-9.

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