Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00184)
MIC Name Bacteroides uniformis (CFB bacteria)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides uniformis
Oxygen Sensitivity Anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Commensal
Genome Size (bp) 4717497
No. of Coding Genes 4296
No. of Non-Coding Genes 63
No. of Small Non-Coding Genes 63
No. of Gene Transcripts 4359
No. of Base Pairs 4652458
Description Bacteroides uniformis is a species of anaerobic, Gram-negative, rod shaped bacteria assigned to the phylum Bacteroidetes. It is found in the human and swine intestinal tract, but can be pathogenic in other locations.
External Links Taxonomy ID
820
Genome Assembly ID
ASM157855v1
GOLD Organism ID
Go0000893
Disease Relevance
          Cerebral Infarction  [ICD-11: 8B11]
             Description Bacteroidia was decreased in Cerebral infarction patient stool. [1]
          Coeliac disease  [ICD-11: DA95]
             Description Bacteroides uniformis Bacteroides uniformis was more abundant in controls than in patients with coeliac disease. [2]
          Crohn disease  [ICD-11: DD70]
             Description Bacteroides uniformis is downregulated in disease expression of crohns disease. [3]
Host Genetic Factors (HGFs)
          CD44
             HGF ID HGF2333 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of CD44 significantly decreased the abundance of Bacteroides uniformis (p-value<0.05). [4]
          SMARCAD1
             HGF ID HGF2342 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of SMARCAD1 was significantly associated with a decrease of Bacteroides uniformis (p-value<0.05). [5]
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description An higher AMY1-CN has been associated with the abundance of Bacteroides uniformis. [6]
          rs4777927
             HGF ID HGF1581 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4777927 SNP was significantly associated with the abundance of Bacteroidia (p-value=1.67E-08). [7]
          rs10037689
             HGF ID HGF2053 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs10037689 SNP was significantly associated with the abundance of Bacteroides uniformis (p-value<1.00E-08). [8]
          rs7517810
             HGF ID HGF2531 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7517810 SNP is associated with the abundance of Bacteroides uniformis. [9]
          rs921720
             HGF ID HGF2528 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-UV)
             Description The rs921720 SNP is associated with the abundance of Bacteroides uniformis. [9]
          rs17229285
             HGF ID HGF2578 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs17229285 SNP is associated with the abundance of Bacteroides uniformis. [9]
          rs1440088
             HGF ID HGF2608 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1440088 SNP is associated with the abundance of Bacteroides uniformis. [9]
          rs6716753
             HGF ID HGF2609 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6716753 SNP is associated with the abundance of Bacteroides uniformis. [9]
          rs1819333
             HGF ID HGF2529 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1819333 SNP is associated with the abundance of Bacteroides uniformis. [9]
          rs13277237
             HGF ID HGF2598 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs13277237 SNP is associated with the abundance of Bacteroides uniformis. [9]
          rs2836878
             HGF ID HGF2610 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs2836878 SNP is associated with the abundance of Bacteroides uniformis. [9]
          rs174537
             HGF ID HGF2611 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs174537 SNP is associated with the abundance of Bacteroides uniformis. [9]
          rs1847472
             HGF ID HGF2550 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1847472 SNP is associated with the abundance of Bacteroides uniformis. [9]
          rs3091315
             HGF ID HGF2612 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs3091315 SNP is associated with the abundance of Bacteroides uniformis. [9]
Host Immune Factors (HIFs)
          C-C motif chemokine 13
             HIF ID HIFM0018 HIF Info       Class Antimicrobial peptide (AMP)
             Description Bacteroidetes in particular the class of Bacteroidia was correlated with expression of CCL13. [10]
          Perforin
             HIF ID HIFM0320 HIF Info       Class Antimicrobial peptide (AMP)
             Description Bacteroides uniformis uses MACPF (membrane attack complex/perforin) toxinsBSAP-1 and BSAP-2, respectivelyfor intraspecies killing. [11]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Bacteroidia is associated with IL-6 expression. [12]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Bacteroides uniformis is negatively associated with IgA. [13]
Environmental Factor(s)
             Disbiome ID
      642
             gutMDisorder ID
      gm0088
References
1 The characteristics analysis of intestinal microecology on cerebral infarction patients and its correlation with apolipoprotein E. Medicine (Baltimore). 2018 Oct;97(41):e12805. doi: 10.1097/MD.0000000000012805.
2 Intestinal Bacteroides species associated with coeliac disease. J Clin Pathol. 2010 Dec;63(12):1105-11. doi: 10.1136/jcp.2010.076950. Epub 2010 Oct 23.
3 The impact of the gut microbiota on human health: an integrative view. Cell. 2012 Mar 16;148(6):1258-70. doi: 10.1016/j.cell.2012.01.035.
4 CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice.Eur J Immunol. 2017 Jul;47(7):1188-1199. doi: 10.1002/eji.201646792. Epub 2017 Jun 6.
5 Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium.Genome Biol. 2020 Mar 11;21(1):64. doi: 10.1186/s13059-020-01976-7.
6 Pretreatment Prevotella-to-Bacteroides ratio and salivary amylase gene copy number as prognostic markers for dietary weight loss.Am J Clin Nutr. 2020 May 1;111(5):1079-1086. doi: 10.1093/ajcn/nqaa007.
7 Genetic Determinants of the Gut Microbiome in UK Twins.Cell Host Microbe. 2016 May 11;19(5):731-43. doi: 10.1016/j.chom.2016.04.017.
8 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
9 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
10 Duodenal Mucosa of Patients With Type 1 Diabetes Shows Distinctive Inflammatory Profile and Microbiota.J Clin Endocrinol Metab. 2017 May 1;102(5):1468-1477. doi: 10.1210/jc.2016-3222.
11 Bacterial antagonism in host-associated microbial communities.Science. 2018 Sep 21;361(6408):eaat2456. doi: 10.1126/science.aat2456.
12 Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Sci Transl Med. 2013 Jul 10;5(193):193ra91. doi: 10.1126/scitranslmed.3006438.
13 Impact of a 3-Months Vegetarian Diet on the Gut Microbiota and Immune Repertoire.Front Immunol. 2018 Apr 27;9:908. doi: 10.3389/fimmu.2018.00908. eCollection 2018.

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