General Information of HIF (ID: HIFM0320)
HIF Name	Perforin
HIF Classification	Antimicrobial peptide (AMP)
Description	Perforin LL-23 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]

Microbe Species (MIC) Regulated by This HIF
Bacteroides fragilis (CFB bacteria)			MIC00158
Description	Bacteroides fragilis could use MACPF (membrane attack complex/perforin) toxinsBSAP-1 and BSAP-2, respectivelyfor intraspecies killing.				[2]
Bacteroides sp. (CFB bacteria)			MIC00176
Description	The most abundant and stable members of the gut microbiota, Bacteroides spp.produce membrane attack complex/perforin (MACPF) domain pore-forming toxins.				[2]
Bacteroides thetaiotaomicron (CFB bacteria)			MIC00179
Description	Membrane-attack complex/perforin (MACPF) family protein is from the human gut symbiont Bacteroides thetaiotaomicron.				[3]
Bacteroides uniformis (CFB bacteria)			MIC00184
Description	Bacteroides uniformis uses MACPF (membrane attack complex/perforin) toxinsBSAP-1 and BSAP-2, respectivelyfor intraspecies killing.				[2]

References
1	Antimicrobial peptides and the skin immune defense system.J Allergy Clin Immunol. 2008 Aug;122(2):261-6. doi: 10.1016/j.jaci.2008.03.027. Epub 2008 Apr 25.
2	Bacterial antagonism in host-associated microbial communities.Science. 2018 Sep 21;361(6408):eaat2456. doi: 10.1126/science.aat2456.
3	Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron.Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1297-305. doi: 10.1107/S1744309110023055. Epub 2010 Jul 31.

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