Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00110)
MIC Name Atopobium vaginae (actinobacteria)
Body Site Vagina
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Coriobacteriia
Order: Coriobacteriales
Family: Atopobiaceae
Genus: Atopobium
Species: Atopobium vaginae
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory
Gram Positive
Host Relationship Opportunistic pathogen
Genome Size (bp) 1449613
No. of Coding Genes 1109
No. of Non-Coding Genes 49
No. of Small Non-Coding Genes 49
No. of Gene Transcripts 1158
No. of Base Pairs 1483295
Description Atopobium vaginae is a facultative anaerobic, Gram-positive rod-shaped or elliptical coccobacilli found as single elements or in pairs or short chains. It is typically isolated from 80% of women with bacterial vaginosis and it is implicated in treatment failures. Invasive infections such as bacteremia have been reported.
External Links Taxonomy ID
82135
Genome Assembly ID
ASM104977v1
GOLD Organism ID
Go0003994
Disease Relevance
          Vaginitis  [ICD-11: GA02]
             Description Atopobium vaginae is an important component of the complex abnormal vaginal flora in bacterial vaginosis. [1]
          Vaginitis  [ICD-11: GA02]
             Description Atopobium vaginae is associated with Bacterial vaginosis. [2]
Host Genetic Factors (HGFs)
          rs9558805
             HGF ID HGF1678 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs9558805 SNP is significantly associated with the abundance of gut microbiota Atopobium (p-value<5.00E-05). [3]
          rs16928751
             HGF ID HGF1937 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The variant gene ADIPOR2 of innate immunity rs16928751 is significantly associated with the abundance of gut micriobiota Atopobium (p-value=0.0206). [4]
Host Immune Factors (HIFs)
          C-C motif chemokine 13
             HIF ID HIFM0018 HIF Info       Class Antimicrobial peptide (AMP)
             Description The CCL13 significantly altered by co-culture with Atopobium and Porphyromonas. [5]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Women with incident bacterial vaginosis higher concentrations of Atopobium vaginae when concentrations of proinflammatory cytokines (IL-1beta were increased. [6]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description IL-6 was secreted by vaginal epithelial cells in response to the activity of Atopobium vaginae. [7]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description IL-8 was secreted by vaginal epithelial cells in response to the activity of Atopobium vaginae. [7]
          IL-12 subunit p70
             HIF ID HIFM0264 HIF Info       Class Cytokine (Cyt)
             Description Atopobium is associated with IL-12p70. [6]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description The abundance of Atopobium vaginae is associated with the NFkappaB signaling pathway. [7]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description Atopobium vaginae induction of IL-8 is mediated by TLR2. [7]
Environmental Factor(s)
             Disbiome ID
      457
             gutMDisorder ID
      gm0062
References
1 An update on the role of Atopobium vaginae in bacterial vaginosis: what to consider when choosing a treatment A mini review. Arch Gynecol Obstet. 2019 Jul;300(1):1-6. doi: 10.1007/s00404-019-05142-8. Epub 2019 Apr 5.
2 Molecular assessment of bacterial vaginosis by Lactobacillus abundance and species diversity. BMC Infect Dis. 2016 Apr 23;16:180. doi: 10.1186/s12879-016-1513-3.
3 Assessing the Relationship Between Gut Microbiota and Bone Mineral Density.Front Genet. 2020 Jan 31;11:6. doi: 10.3389/fgene.2020.00006. eCollection 2020.
4 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
5 Atopobium vaginae And Porphyromonas somerae Induce Proinflammatory Cytokines Expression In Endometrial Cells: A Possible Implication For Endometrial Cancer. Cancer Manag Res. 2019 Sep 23;11:8571-8575. doi: 10.2147/CMAR.S217362. eCollection 2019.
6 A longitudinal analysis of the vaginal microbiota and vaginal immune mediators in women from sub-Saharan Africa. Sci Rep. 2017 Sep 20;7(1):11974. doi: 10.1038/s41598-017-12198-6.
7 Atopobium vaginae triggers an innate immune response in an in vitro model of bacterial vaginosis. Microbes Infect. 2008 Apr;10(4):439-46. doi: 10.1016/j.micinf.2008.01.004. Epub 2008 Jan 12.

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