Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0264)
HIF Name
IL-12 subunit p70
HIF Synonym(s)
interleukin 2 receptor, beta chain, Il2rb, p70, CD122, IL15Rbeta, Il-2Rbeta, IL-15Rbeta, Il-2/15Rbeta
HIF Classification
Cytokine (Cyt)
Description Interleukin-12, p70 (IL-12 p70) is a disulfide-linked heterodimeric 70-kDa cytokine composed of a 197 amino acid 35-kDA (p35) subunit and a 306 amino acid 40-kDa (p40) subunit. [1]
Microbe Species (MIC) Regulated by This HIF
         Atopobium vaginae (actinobacteria) MIC00110
             Description Atopobium is associated with IL-12p70. [2]
         Corynebacterium amycolatum (actinobacteria) MIC00450
             Description Corynebacterium amycolatum stimulated high IL-12 p70 production. [3]
         Enterococcus faecalis (firmicutes) MIC00548
             Description Enterococcus faecalis is associated with IL-12p70. [4]
         Enterococcus gallinarum (firmicutes) MIC00550
             Description The different streptococci could induce varying levels of the cytokines IL-12p70. [5]
         Prevotella salivae (CFB bacteria) MIC01023
             Description Prevotella salivae could decrease IL-12p70. [6]
         Streptococcus gordonii (firmicutes) MIC01252
             Description The abundance of Streptococcus gordonii is associated with IL-12p70. [7]
References
1 Exhaustive exercise and type-1/type-2 cytokine balance with special focus on interleukin-12 p40/p70.Exerc Immunol Rev. 2003;9:48-57.
2 A longitudinal analysis of the vaginal microbiota and vaginal immune mediators in women from sub-Saharan Africa. Sci Rep. 2017 Sep 20;7(1):11974. doi: 10.1038/s41598-017-12198-6.
3 Cytokine Levels in the In Vitro Response of T Cells to Planktonic and Biofilm Corynebacterium amycolatum. Pol J Microbiol. 2019 Dec;68(4):457-464. doi: 10.33073/pjm-2019-045. Epub 2019 Oct 31.
4 Enterococcus faecalis Modulates Immune Activation and Slows Healing During Wound Infection. J Infect Dis. 2017 Dec 19;216(12):1644-1654. doi: 10.1093/infdis/jix541.
5 Immunomodulatory properties of Streptococcus and Veillonella isolates from the human small intestine microbiota. PLoS One. 2014 Dec 5;9(12):e114277. doi: 10.1371/journal.pone.0114277. eCollection 2014.
6 The immune response to Prevotella bacteria in chronic inflammatory disease. Immunology. 2017 Aug;151(4):363-374. doi: 10.1111/imm.12760. Epub 2017 Jun 20.
7 Synergistic BM-DC activation and immune induction by the oral vaccine vector Streptococcus gordonii and exogenous tumor necrosis factor. Mol Immunol. 2009 May;46(8-9):1883-91. doi: 10.1016/j.molimm.2009.02.008. Epub 2009 Mar 10.

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