Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00450)
MIC Name Corynebacterium amycolatum (actinobacteria)
MIC Synonyms Corynebacterium asperum
Body Site Skin
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Corynebacteriaceae
Genus: Corynebacterium
Species: Corynebacterium amycolatum
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Opportunistic pathogen
Genome Size (bp) 2513912
No. of Coding Genes 2076
No. of Non-Coding Genes 63
No. of Small Non-Coding Genes 63
No. of Gene Transcripts 2173
No. of Pseudogenes 34
No. of Base Pairs 2460257
Description Corynebacterium amycolatum is a facultatively anaerobic, Gram positive bacilli arranged in palisades bacterium. It is a relatively rare cause of pyogenic ear infections and has been implicated in wound and urinary tract infections.
External Links Taxonomy ID
43765
Genome Assembly ID
ASM172225v1
GOLD Organism ID
Go0004143
Disease Relevance
          Autoimmune liver disease  [ICD-11: DB96]
             Description Corynebacterium was associated with PSC-IBD(primary sclerosing cholangitis-inflammatory bowel disease), but not with isolated PSC. [1]
          Ear infection  [ICD-11: AA80]
             Description Corynebacterium amycolatum is a relatively rare cause of pyogenic ear infections. [2]
          Inflammatory disorders of breast  [ICD-11: GB21]
             Description Corynebacterium amycolatum was associated with cystic neutrophilic granulomatous mastitis. [3]
          Ulcerative colitis  [ICD-11: DD71]
             Description Corynebacterium was associated with PSC-IBD(primary sclerosing cholangitis-inflammatory bowel disease), but not with isolated PSC. [1]
          Urinary tract infection  [ICD-11: GC08]
             Description Urinary tract infection was associated with Corynebacterium amycolatum infection. [4]
Host Genetic Factors (HGFs)
          hsa-miR-29c-3p
             HGF ID HGF0175 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-29c expression examination profile following Corynebacterium parvum-induced inflammation in mice revealed NO-dependent modulation. [5]
          rs11837284
             HGF ID HGF2224 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs11837284 SNP was significantly associated with the abundance of Corynebacterium (p-value=1.53E-06). [6]
          rs10506621
             HGF ID HGF2225 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs10506621 SNP was significantly associated with the abundance of Corynebacterium (p-value=1.53E-06). [6]
Host Immune Factors (HIFs)
          Ribonuclease 7
             HIF ID HIFM0201 HIF Info       Class Antimicrobial peptide (AMP)
             Description The skin commensal and opportunistic pathogen Corynebacterium amycolatum induced the expression of the antimicrobial protein RNase 7 in keratinocytes. [7]
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Corynebacterium amycolatum infection stimulated high IL-10 production. [8]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Corynebacterium amycolatum stimulated high IL-1beta production. [8]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Corynebacterium amycolatum stimulated high IL-8 production. [8]
          IL-12 subunit p70
             HIF ID HIFM0264 HIF Info       Class Cytokine (Cyt)
             Description Corynebacterium amycolatum stimulated high IL-12 p70 production. [8]
          T cells
             HIF ID HIFC0002 HIF Info       Class T cells (TCs)
             Description T cells produced anti-inflammatory (IL-10) cytokines in response to planktonic and biofilm Corynebacterium amycolatum. [8]
Environmental Factor(s)
             Disbiome ID
      250
             gutMDisorder ID
      gm0233
References
1 Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol. 2017 Jul 7;23(25):4548-4558. doi: 10.3748/wjg.v23.i25.4548.
2 Corynebacterium amycolatum: An Unexpected Pathogen in the Ear. J Clin Diagn Res. 2015 Dec;9(12):DD01-3. doi: 10.7860/JCDR/2015/15134.7002. Epub 2015 Dec 1.
3 Cystic neutrophilic granulomatous mastitis: A clinicopathologic study of a distinct entity with supporting evidence of a role for Corynebacterium-targeted therapy. Ann Diagn Pathol. 2018 Dec;37:51-56. doi: 10.1016/j.anndiagpath.2018.08.005. Epub 2018 Aug 24.
4 Corynebacterium species isolated from patients with mastitis. Clin Infect Dis. 2002 Dec 1;35(11):1434-40. doi: 10.1086/344463. Epub 2002 Nov 14.
5 NO and Pancreatic Cancer: A Complex Interaction with Therapeutic Potential. Antioxid Redox Signal. 2017 Jun 10;26(17):1000-1008. doi: 10.1089/ars.2016.6809. Epub 2016 Sep 22.
6 Genome-Wide Association Studies of the Human Gut Microbiota.PLoS One. 2015 Nov 3;10(11):e0140301. doi: 10.1371/journal.pone.0140301. eCollection 2015.
7 Skin microbiota and human 3D skin models.Exp Dermatol. 2018 May;27(5):489-494. doi: 10.1111/exd.13517. Epub 2018 Apr 10.
8 Cytokine Levels in the In Vitro Response of T Cells to Planktonic and Biofilm Corynebacterium amycolatum. Pol J Microbiol. 2019 Dec;68(4):457-464. doi: 10.33073/pjm-2019-045. Epub 2019 Oct 31.

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