Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0201)
HIF Name	Ribonuclease 7
HIF Synonym(s)	Rnase 7, RNase 7
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Antibiotic; Antimicrobial; Endonuclease; Hydrolase; Nuclease
Description	RNase 7 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.		[1]
Pfam	Pancreatic ribonuclease (PF00074 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	RNAS7_HUMAN
	APD ID	AP02079

Microbe Species (MIC) Regulated by This HIF
Corynebacterium amycolatum (actinobacteria)		MIC00450
Description	The skin commensal and opportunistic pathogen Corynebacterium amycolatum induced the expression of the antimicrobial protein RNase 7 in keratinocytes.		[2]
Enterococcus faecium (firmicutes)		MIC00549
Description	Antimicrobial activity RNase 7 (0.33M) was incubated without RNase inhibitor reduced the colony-forming units (CFUs) of Enterococcus faecium.		[3]
Escherichia coli (enterobacteria)		MIC00516
Description	RNase 7 showed potent antimicrobial activity against uropathogenic Escherichia coli.		[3]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Skin microbiota and human 3D skin models.Exp Dermatol. 2018 May;27(5):489-494. doi: 10.1111/exd.13517. Epub 2018 Apr 10.
3	An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ribonuclease 7 in the human urinary tract.Kidney Int. 2014 May;85(5):1179-91. doi: 10.1038/ki.2013.395. Epub 2013 Oct 9.

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