Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01252)
MIC Name Streptococcus gordonii (firmicutes)
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus gordonii
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Genome Size (bp) 2196662
No. of Coding Genes 2085
No. of Non-Coding Genes 66
No. of Small Non-Coding Genes 66
No. of Gene Transcripts 2151
No. of Base Pairs 2197447
Description Streptococcus gordonii is a facultative anaerobic, Gram positive species. It is a part of the group viridians of Strepotococci, nonpathogenic commensal streptococci, which are integral members of the human oral flora. S.gordonii plays an integral role in initiating colonization by creating surfaces for other colonizers to adhere to.S.gordonii also causes bacterial endocarditis by entering the blood stream usually after oral trauma.
External Links Taxonomy ID
1302
Genome Assembly ID
ASM95992v1
GOLD Organism ID
Go0005216
Disease Relevance
          Cystic fibrosis  [ICD-11: CA25]
             Description Streptococcus gordonii was associated with cystic fibrosis. [1]
          Infectious endocarditis  [ICD-11: BB40]
             Description The clinical presentation of Streptococcus gordonii infection may present as subacute bacterial endocarditis. [2]
Host Immune Factors (HIFs)
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Stimulation with Streptococcus gordonii elicited the expression of IL-10. [3]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Following co-stimulation with TNF and Streptococcus gordoniii, the synergistic induction of IL-6 could still be observed. [3]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description TNF could prime BM-DCs to better respond to Streptococcus gordonii, through a mechanism at least partially involving TLR-2 upregulation. [3]
          IL-12 subunit p70
             HIF ID HIFM0264 HIF Info       Class Cytokine (Cyt)
             Description The abundance of Streptococcus gordonii is associated with IL-12p70. [3]
          Mouse bone marrow-derived dendritic cells
             HIF ID HIFC0005 HIF Info       Class Dendritic cells (DCs)
             Description Stimulation with Streptococcus gordonii resulted in increased surface expression of MHCII, CD80, and CD86, compared to unstimulated BM-DCs. [3]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description TNF is able to prime BM-DCs to better respond to Streptococcus gordonii, through a mechanism at least partially involving TLR-2 upregulation. [3]
Environmental Factor(s)
             Disbiome ID
      352
             gutMDisorder ID
      gm0624
             aBiofilm Organism
      Streptococcus gordonii
References
1 Environment and colonisation sequence are key parameters driving cooperation and competition between Pseudomonas aeruginosa cystic fibrosis strains and oral commensal streptococci. PLoS One. 2015 Feb 24;10(2):e0115513. doi: 10.1371/journal.pone.0115513. eCollection 2015.
2 Plantar Purpura as the Initial Presentation of Viridians Streptococcal Shock Syndrome Secondary to Streptococcus gordonii Bacteremia.Can J Infect Dis Med Microbiol. 2016;2016:9463895. doi: 10.1155/2016/9463895. Epub 2016 Apr 17.
3 Synergistic BM-DC activation and immune induction by the oral vaccine vector Streptococcus gordonii and exogenous tumor necrosis factor. Mol Immunol. 2009 May;46(8-9):1883-91. doi: 10.1016/j.molimm.2009.02.008. Epub 2009 Mar 10.

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