Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFC0005)
HIF Name	Mouse bone marrow-derived dendritic cells
HIF Synonym(s)	BM-DCs, Mouse bone marrow-derived dendritic cells
HIF Classification	Dendritic cells (DCs)
Description	Murine bone marrowderived DCs (BM-DCs) are the closest known equivalent of the blood monocyte-derived DCs that have been used for human therapy	[1]

Microbe Species (MIC) Regulated by This HIF
Entamoeba histolytica (eukaryotes)		MIC00528
Description	Bone marrow-derived dendritic cells from mouse was sufficient to provide protection against Entamoeba histolytica.		[2]
Streptococcus gordonii (firmicutes)		MIC01252
Description	Stimulation with Streptococcus gordonii resulted in increased surface expression of MHCII, CD80, and CD86, compared to unstimulated BM-DCs.		[3]

References
1	Toxicity of silver nanoparticles in mouse bone marrow-derived dendritic cells: Implications for phenotype.J Immunotoxicol. 2019 Dec;16(1):54-62. doi: 10.1080/1547691X.2019.1584652. Epub 2019 Apr 2.
2	Bone marrow dendritic cells from mice with an altered microbiota provide interleukin 17A-dependent protection against Entamoeba histolytica colitis.mBio. 2014 Nov 4;5(6):e01817. doi: 10.1128/mBio.01817-14.
3	Synergistic BM-DC activation and immune induction by the oral vaccine vector Streptococcus gordonii and exogenous tumor necrosis factor. Mol Immunol. 2009 May;46(8-9):1883-91. doi: 10.1016/j.molimm.2009.02.008. Epub 2009 Mar 10.

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