General Information of HIF (ID: HIFM0025)
HIF Name	C-C motif chemokine 22
HIF Synonym(s)	Ccl22, MDC
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Cytokine
Description	CCL22 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Pfam	Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway	C-type lectin receptor signaling pathway (hsa04625 )
	Chemokine signaling pathway (hsa04062 )
	Cytokine-cytokine receptor interaction (hsa04060 )
	Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	CCL22_HUMAN
	APD ID	AP02098

Microbe Species (MIC) Regulated by This HIF
Bifidobacterium animalis subsp. lactis (actinobacteria)			MIC00216
Description	The abundance of circulating CCL22 was lower in the group supplemented with Bifidobacterium animalis subsp.lactis.				[2]
Prevotella sp. (CFB bacteria)			MIC01024
Description	Patients with a Prevotella-rich gut enterotype displayed increased serum levels of the chemokines CCL22.				[3]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Integrated Role of Bifidobacterium animalis subsp. lactis Supplementation in Gut Microbiota, Immunity, and Metabolism of Infant Rhesus Monkeys.mSystems. 2016 Nov 29;1(6):e00128-16. doi: 10.1128/mSystems.00128-16. eCollection 2016 Nov-Dec.
3	Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients.Nat Commun. 2019 Dec 13;10(1):5711. doi: 10.1038/s41467-019-13751-9.

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