General Information of HGF (ID: HGF1279)
HGF Name	rs4986790
Source	Homo sapiens
HGF Classification	Single Nucleotide Polymorphism: Missense variant (SNP-MV)
Gene Location	chr9:117713024
SNP in Gene	TLR4

Microbe Species (MIC) Regulated by This HGF
Bacteroides sp. (CFB bacteria)			MIC00176
Description	A variant in TLR4 (rs4986790) was found to be associated with an increase in Bacteroides.				[1]
Cutibacterium acnes (actinobacteria)			MIC01031
Description	The rs4986790 SNP is significantly associated with the abundance of Propionibacterium acnes (p-value<0.05).				[2]
Escherichia coli (enterobacteria)			MIC00516
Description	The TLR4 rs4986790 SNP is significantly associated with Escherichia coli colonization in the first month of life.				[3]
Gardnerella vaginalis (actinobacteria)			MIC00626
Description	The varian TLR4 rs4986790 was associated with an increase in Gardnerella vaginalis.				[1]
Porphyromonas sp. (CFB bacteria)			MIC01003
Description	The variant in TLR4 rs4986790 was associated with an increase in Porphyromonas.				[1]
Prevotella sp. (CFB bacteria)			MIC01024
Description	The variant in TLR4 rs4986790 was associated with an increase in Prevotella.				[1]

References
1	Genetic association of Toll-like receptor 4 with cervical cytokine concentrations during pregnancy.Genes Immun. 2009 Oct;10(7):636-40. doi: 10.1038/gene.2009.47. Epub 2009 Jun 25.
2	Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata.J Eur Acad Dermatol Venereol. 2012 Dec;26(12):1538-43. doi: 10.1111/j.1468-3083.2011.04338.x. Epub 2011 Nov 16.
3	Host-microbial interactions in childhood atopy: toll-like receptor 4 (TLR4), CD14, and fecal Escherichia coli.J Allergy Clin Immunol. 2010 Jan;125(1):231-6.e1-5. doi: 10.1016/j.jaci.2009.10.011.

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