Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01031)
MIC Name Cutibacterium acnes (actinobacteria)
MIC Synonyms Bacillus acnes
Body Site Skin
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Propionibacteriales
Family: Propionibacteriaceae
Genus: Cutibacterium
Species: Cutibacterium acnes
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Commensal
Genome Size (bp) 2399738
No. of Coding Genes 2261
No. of Non-Coding Genes 52
No. of Small Non-Coding Genes 52
No. of Gene Transcripts 2313
No. of Base Pairs 2497951
Description Cutibacterium acnes is the relatively slow-growing, typically aerotolerant anaerobic, Gram-positive bacterium linked to the skin condition of acne; it can also cause chronic blepharitis and endophthalmitis, the latter particularly following intraocular surgery.
External Links Taxonomy ID
1747
Genome Assembly ID
ASM73046v1
GOLD Organism ID
Go0543960
Disease Relevance
          Parkinsonism  [ICD-11: 8A00]
             Description Propionibacterium acnes was associated with parkinsons disease. [1]
Host Genetic Factors (HGFs)
          rs9907842
             HGF ID HGF1917 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs9907842 SNP was significantly associated with the abundance of Propionibacterium acnes (p-value<1.00E-08). [2]
          rs62441148
             HGF ID HGF2002 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs62441148 SNP was significantly associated with the abundance of Propionibacterium acnes (p-value<1.00E-08). [2]
          rs58943042
             HGF ID HGF1986 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs58943042 SNP was significantly associated with the abundance of Propionibacterium acnes (p-value<1.00E-08). [2]
          rs55786536
             HGF ID HGF2073 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs55786536 SNP was significantly associated with the abundance of Propionibacterium acnes (p-value<1.00E-08). [2]
          rs4986791
             HGF ID HGF1278 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs4986791 SNP is significantly associated with the abundance of Propionibacterium acnes (p-value<0.05). [3]
          rs4986790
             HGF ID HGF1279 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs4986790 SNP is significantly associated with the abundance of Propionibacterium acnes (p-value<0.05). [3]
          rs146599125
             HGF ID HGF1861 HGF Info       Class Single Nucleotide Polymorphism: Downstream variant (SNP-DV)
             Description The rs146599125 SNP was significantly associated with the abundance of Propionibacterium acnes (p-value<1.00E-08). [2]
          rs12483628
             HGF ID HGF2102 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs12483628 SNP was significantly associated with the abundance of Propionibacterium acnes (p-value<1.00E-08). [2]
Host Immune Factors (HIFs)
          T-cell surface glycoprotein CD1a
             HIF ID HIFM0038 HIF Info       Class Checkpoint molecule (CM)
             Description The increased Propionibacterium acnes abundance was associated with the expression of langerhans cell marker CD1a/CD207. [4]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Propionibacterium acnes could mediate proinflammatory cytokines, such as IL-1beta. [5]
          Skin conventional dendritic cells
             HIF ID HIFC0161 HIF Info       Class Dendritic cells (DCs)
             Description Skin conventional dendritic cells(cDC1s), regulated the magnitude of the immune response to Propionibacterium acnes in the murine dermis. [6]
          CD11c+ dendritic cells
             HIF ID HIFC0204 HIF Info       Class Dendritic cells (DCs)
             Description CD11c+ DCs are critical for hepatic granuloma formation in subjects injected with heat-killed Propionibacterium acnes. [6]
          Immunoglobulin E
             HIF ID HIFM0271 HIF Info       Class Immunoglobulin (Ig)
             Description A low relative abundance of Actinobacteria phylum (Propionibacterium acnes)is associated with individuals with high total serum IgE levels. [7]
Environmental Factor(s)
             Disbiome ID
      1640
References
1 P. acnes-Driven Disease Pathology: Current Knowledge and Future Directions. Front Cell Infect Microbiol. 2017 Mar 14;7:81. doi: 10.3389/fcimb.2017.00081. eCollection 2017.
2 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
3 Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata.J Eur Acad Dermatol Venereol. 2012 Dec;26(12):1538-43. doi: 10.1111/j.1468-3083.2011.04338.x. Epub 2011 Nov 16.
4 Microbiome in the hair follicle of androgenetic alopecia patients.PLoS One. 2019 May 3;14(5):e0216330. doi: 10.1371/journal.pone.0216330. eCollection 2019.
5 Suppression of Propionibacterium acnes-Induced Skin Inflammation by Laurus nobilis Extract and Its Major Constituent Eucalyptol. Int J Mol Sci. 2019 Jul 17;20(14):3510. doi: 10.3390/ijms20143510.
6 A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGF-Mediated Recruitment of Neutrophils.Immunity. 2019 Apr 16;50(4):1069-1083.e8. doi: 10.1016/j.immuni.2019.03.001. Epub 2019 Mar 27.
7 Dysbiosis of Inferior Turbinate Microbiota Is Associated with High Total IgE Levels in Patients with Allergic Rhinitis.Infect Immun. 2018 Mar 22;86(4):e00934-17. doi: 10.1128/IAI.00934-17. Print 2018 Apr.

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