Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00732)
MIC Name Lactobacillus rhamnosus (firmicutes)
MIC Synonyms Lactobacillus casei subsp. rhamnosus
Body Site Ocular Surface
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus rhamnosus
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Probiotic
Genome Size (bp) 3010111
No. of Coding Genes 2640
No. of Non-Coding Genes 61
No. of Small Non-Coding Genes 61
No. of Gene Transcripts 2701
No. of Base Pairs 2922140
Description Lactobacillus rhamnosus is a short, Gram-positive, heterofermentative, facultative anaerobic, non-spore-forming rod bacterium that often appears in chains. This bacterium that originally was considered to be a subspecies of L. casei, but genetic research found it to be a species of its own. Some strains of L. rhamnosus bacteria are being used as probiotics, and are particularly useful in treating female-related infections.
External Links Taxonomy ID
47715
Genome Assembly ID
ASM74307v1
GOLD Organism ID
Go0005383
Disease Relevance
          Anxiety disorder  [ICD-11: 6B00]
             Description Lactobacillus rhamnosus can ameliorate Anxiety. [1]
          Depression  [ICD-11: 6A70]
             Description Lactobacillus rhamnosus can ameliorate Depression. [1]
          Infectious endocarditis  [ICD-11: BB40]
             Description Endocarditis due to Lactobacillus rhamnosus in a patient with bicuspid aortic valve: Potential role for the consumption of probiotics. [2]
          Liver abscess  [ICD-11: DB90]
             Description Lactobacillus rhamnosus was associated with liver abscess. [3]
          Post traumatic stress disorder  [ICD-11: 6B40]
             Description Lactobacillus rhamnosus was associated with posttraumatic stress disorder. [1]
          Type 2 diabetes mellitus  [ICD-11: 5A11]
             Description Lactobacillus rhamnosus was associated with type 2 diabetes. [4]
          Vaginitis  [ICD-11: GA02]
             Description Lactobacillus rhamnosus was associated with bacterial vaginosis. [5]
Host Genetic Factors (HGFs)
          CD44
             HGF ID HGF2333 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description Lactobacillus rhamnosus had a significant difference in the percentage abundance between the EAE-induced CD44 wide type and the CD44 knock out mice (p-value<0.05). [6]
          rs7927894
             HGF ID HGF2249 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7927894 SNP was significantly associated with the abundance of Lactobacillus rhamnosus (p-value=0.0138). [7]
          rs5743409
             HGF ID HGF1829 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The rs5743409 SNP was significantly associated with the abundance of Lactobacillus rhamnosus HN001 (p-value=0.0016). [7]
          rs5743399
             HGF ID HGF1974 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs5743399 SNP was significantly associated with the abundance of Lactobacillus rhamnosus HN001 (p-value=0.0143). [7]
          rs3815735
             HGF ID HGF1320 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs3815735 SNP was significantly associated with the abundance of Lactobacillus rhamnosus HN001 (p-value=0.0063). [7]
          rs3794379
             HGF ID HGF1361 HGF Info       Class Single Nucleotide Polymorphism: Downstream variant (SNP-DV)
             Description The rs3794379 SNP was significantly associated with the abundance of Lactobacillus rhamnosus HN001 (p-value=0.0030). [7]
          rs3756688
             HGF ID HGF1322 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The rs3756688 SNP was significantly associated with the abundance of Lactobacillus rhamnosus HN001 (p-value=0.0104). [7]
          rs2738182
             HGF ID HGF1830 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The rs2738182 SNP was significantly associated with the abundance of Lactobacillus rhamnosus HN001 (p-value=4.77E-04). [7]
          rs2569190
             HGF ID HGF1270 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2569190 SNP was significantly associated with the abundance of Lactobacillus rhamnosus HN001 (p-value=0.0126). [7]
          rs2107356
             HGF ID HGF1724 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The rs2107356 SNP was significantly associated with the abundance of Lactobacillus rhamnosus HN001 (p-value=8.66E-04). [7]
          rs2057768
             HGF ID HGF2184 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs2057768 SNP was significantly associated with the abundance of Lactobacillus rhamnosus HN001 (p-value=0.0039). [7]
          rs20541
             HGF ID HGF1733 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs20541 SNP was significantly associated with the abundance of Lactobacillus rhamnosus HN001 (p-value=8.59E-04). [7]
          rs1801275
             HGF ID HGF1723 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs1801275 SNP was significantly associated with the abundance of Lactobacillus rhamnosus HN001 (p-value=0.0058). [7]
          rs1800875
             HGF ID HGF1850 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The rs1800875 SNP was significantly associated with the abundance of Lactobacillus rhamnosus HN001 (p-value=0.0026). [7]
          rs1800825
             HGF ID HGF1631 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1800825 SNP was significantly associated with the abundance of Lactobacillus rhamnosus HN001 (p-value=0.0038). [7]
          rs1423001
             HGF ID HGF1321 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1423001 SNP was significantly associated with the abundance of Lactobacillus rhamnosus HN001 (p-value=0.0132). [7]
          rs1046295
             HGF ID HGF1360 HGF Info       Class Single Nucleotide Polymorphism: Non coding transcript variant (SNP-NCTV)
             Description The rs1046295 SNP was significantly associated with the abundance of Lactobacillus rhamnosus HN001 (p-value=0.0127). [7]
Host Immune Factors (HIFs)
          C-C motif chemokine 17
             HIF ID HIFM0019 HIF Info       Class Antimicrobial peptide (AMP)
             Description The expression of CCL17 concentrations was associated with the nonprobiotic Lactobacillus rhamnosus DSM-20021. [8]
          Human beta-defensin 1
             HIF ID HIFM0090 HIF Info       Class Antimicrobial peptide (AMP)
             Description Lactobacillus rhamnosus GG showed increased killing percentage by hBD-1 at any tested concentration was no more than 4%. [9]
          CD19+CD27+ B cells
             HIF ID HIFC0158 HIF Info       Class B cells (BCs)
             Description CD19+CD27+ B cells increased in the Lactobacillus rhamnosusGG probiotic. [10]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description The combination of iSN34 from Lactobacillus rhamnosus GG could cause synergistic induction (in mouse splenocytes) of IL6. [11]
          Immunoglobulin E
             HIF ID HIFM0271 HIF Info       Class Immunoglobulin (Ig)
             Description IgE immune responses was associated with Lactobacillus rhamnosus. [12]
          CD4+CD25+FOXP3+ regulatory T cells
             HIF ID HIFC0192 HIF Info       Class T cells (TCs)
             Description Lactobacillus rhamnosus is related to the increase of CD4+CD25+FOXP3+ Treg cells in the spleen. [13]
          Toll-like receptor 4
             HIF ID HIFM0219 HIF Info       Class Toll-like receptor (TLR)
             Description The combination of iSN34 from Lactobacillus rhamnosus GG costimulated with agonists for TLR4 could inducte (in mouse splenocytes) of IL6. [11]
          Toll-like receptor 9
             HIF ID HIFM0223 HIF Info       Class Toll-like receptor (TLR)
             Description A low-concentration immune synergistic oligodeoxynucleotide (iSN-ODN, named iSN34) from Lactobacillus rhamnosus GG that has immunosynergistic activity upon costimulation of target cells with ligands of Toll-like receptor 9 (TLR9). [11]
Environmental Factor(s)
             Disbiome ID
      753
             gutMDisorder ID
      gm0408
References
1 Posttraumatic Stress Disorder: Does the Gut Microbiome Hold the Key. Can J Psychiatry. 2016 Apr;61(4):204-13. doi: 10.1177/0706743716635535. Epub 2016 Feb 24.
2 Endocarditis due to Lactobacillus rhamnosus in a patient with bicuspid aortic valve: Potential role for the consumption of probiotics. Med Clin (Barc). 2017 Aug 22;149(4):181-182. doi: 10.1016/j.medcli.2017.03.021. Epub 2017 May 2.
3 Probiotic Properties of Lyophilized Cell Free Extract of Lactobacillus casei. Jundishapur J Nat Pharm Prod. 2013 Aug;8(3):131-7. doi: 10.17795/jjnpp-8564. Epub 2013 Jul 23.
4 Global metabolic interaction network of the human gut microbiota for context-specific community-scale analysis. Nat Commun. 2017 Jun 6;8:15393. doi: 10.1038/ncomms15393.
5 Characterization of culturable vaginal Lactobacillus species among women with and without bacterial vaginosis from the United States and India: a cross-sectional study. J Med Microbiol. 2014 Jul;63(Pt 7):931-935. doi: 10.1099/jmm.0.073080-0. Epub 2014 May 16.
6 CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice.Eur J Immunol. 2017 Jul;47(7):1188-1199. doi: 10.1002/eji.201646792. Epub 2017 Jun 6.
7 Differential modification of genetic susceptibility to childhood eczema by two probiotics.Clin Exp Allergy. 2014 Oct;44(10):1255-65. doi: 10.1111/cea.12394.
8 D-tryptophan from probiotic bacteria influences the gut microbiome and allergic airway disease.J Allergy Clin Immunol. 2017 May;139(5):1525-1535. doi: 10.1016/j.jaci.2016.09.003. Epub 2016 Sep 23.
9 Antimicrobial activity of human -defensins against lactic acid bacteria.Nat Prod Res. 2015;29(22):2164-6. doi: 10.1080/14786419.2014.996754. Epub 2015 Jan 6.
10 Interaction of orally administered Lactobacillus rhamnosus GG with skin and gut microbiota and humoral immunity in infants with atopic dermatitis.Clin Exp Allergy. 2011 Mar;41(3):370-7. doi: 10.1111/j.1365-2222.2010.03657.x. Epub 2010 Dec 1.
11 Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components. Anim Sci J. 2018 Oct;89(10):1504-1511. doi: 10.1111/asj.13082. Epub 2018 Jul 23.
12 Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow's milk allergy.Sci Rep. 2018 Aug 21;8(1):12500. doi: 10.1038/s41598-018-30428-3.
13 Development and maintenance of intestinal regulatory T cells.Nat Rev Immunol. 2016 May;16(5):295-309. doi: 10.1038/nri.2016.36. Epub 2016 Apr 18.

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