General Information of HIF (ID: HIFM0223)
HIF Name	Toll-like receptor 9
HIF Synonym(s)	toll-like receptor 9, Tlr9, TLR-9
HIF Classification	Toll-like receptor (TLR)
Molecular Function	Receptor
Description	TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides.				[1]
Pfam	Leucine Rich repeat (PF13516 )
	Leucine rich repeat (PF13855 )
	Leucine-rich repeat (PF18837 )
	TIR domain (PF01582 )
Pathway	African trypanosomiasis (hsa05143 )
	Chagas disease (American trypanosomiasis) (hsa05142 )
	Herpes simplex virus 1 infection (hsa05168 )
	Malaria (hsa05144 )
	Measles (hsa05162 )
	PD-L1 expression and PD-1 checkpoint pathway in cancer (hsa05235 )
	Salmonella infection (hsa05132 )
	Toll-like receptor signaling pathway (hsa04620 )
	Tuberculosis (hsa05152 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	TLR9_HUMAN

Microbe Species (MIC) Regulated by This HIF
Lactobacillus rhamnosus (firmicutes)			MIC00732
Description	A low-concentration immune synergistic oligodeoxynucleotide (iSN-ODN, named iSN34) from Lactobacillus rhamnosus GG that has immunosynergistic activity upon costimulation of target cells with ligands of Toll-like receptor 9 (TLR9).				[2]

References
1	MGN1703, an immunomodulator and toll-like receptor 9 (TLR-9) agonist: from bench to bedside.Crit Rev Oncol Hematol. 2015 Apr;94(1):31-44. doi: 10.1016/j.critrevonc.2014.12.002. Epub 2014 Dec 19.
2	Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components. Anim Sci J. 2018 Oct;89(10):1504-1511. doi: 10.1111/asj.13082. Epub 2018 Jul 23.

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