General Information of MIC (ID: MIC00064)
MIC Name	Alistipes finegoldii (CFB bacteria)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Rikenellaceae Genus: Alistipes Species: Alistipes finegoldii
Oxygen Sensitivity	Obligate anaerobe
Microbial Metabolism	Saccharolytic; Fermentative
Gram	Negative
Host Relationship	Commensal
Genome Size (bp)	3734239
Description	Alistipes finegoldii, is an obligately anaerobic, Gram negative commensal gut microbe and belonging to the phylum of bacteroidetes. It has been detected in blood samples of human colorectal cancer patients.
External Links	Taxonomy ID	214856
	Genome Assembly ID	ASM26536v1
	GOLD Organism ID	Go0001228
Disease Relevance
Colorectal cancer  [ICD-11: 2B91]
Description	Alistipes finegoldii, was newly identified microbial drivers of colitis and/or CRC(Colorectal cancer).				[1]
Depression  [ICD-11: 6A70]
Description	Alistipes was identified by more than one report as elevated in major depressive disorder.				[2]
Graves disease  [ICD-11: 5A02]
Description	Alistipes was significantly decreased in the genera of the Graves' disease group.				[3]
Inflammatory bowel disease  [ICD-11: DD72]
Description	Inflammatory bowel disease was mainly characterised by decreased abundance of Alistipes finegoldii, which characterize a healthy state microbial core.				[4]
Type 2 diabetes mellitus  [ICD-11: 5A11]
Description	Alistipes was associated with genetic variants in Type 2 diabetes.				[5]

Host Genetic Factors (HGFs)
ZNF396
HGF ID	HGF2321	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The gene ZNF396 with exon deletions was significantly associated with decreased abundance of Alistipes.				[6]
VDR
HGF ID	HGF2353	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The percentage of abundance of Alistipes significantly dropped in VDR deletion mice (p-value<0.05).				[7]
rs5845912
HGF ID	HGF1250	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs5845912 SNP is significantly associated with the abundance of Alistipes (p-value=4.35836E-07).				[6]
rs2274669
HGF ID	HGF1433	HGF Info	Class	Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
Description	The rs2274669 SNP was associated with the abundance of Alistipes (p-value=1.49E-06).				[8]

Host Immune Factors (HIFs)
Interleukin-1 beta
HIF ID	HIFM0138	HIF Info	Class	Cytokine (Cyt)
Description	The Alistipes abundance was negatively correlated with IL-1beta.				[9]
Interferon-6
HIF ID	HIFM0151	HIF Info	Class	Cytokine (Cyt)
Description	Alistipes abundance was negatively correlated with IL-6 expression.				[9]
Tumor necrosis factor
HIF ID	HIFM0226	HIF Info	Class	Cytokine (Cyt)
Description	Alistipes abundance was negatively correlated with TNF-alpha.				[9]
Immunoglobulin E
HIF ID	HIFM0271	HIF Info	Class	Immunoglobulin (Ig)
Description	A gut microbiota dysbiosis was found in non-IgE-mediated cows milk allergy, driven by an enrichment of Alistipes.				[10]

Environmental Factor(s)
Disbiome ID			826
gutMDisorder ID			gm0035

References
1	Novel insights into microbiome in colitis and colorectal cancer. Curr Opin Gastroenterol. 2017 Nov;33(6):422-427. doi: 10.1097/MOG.0000000000000399.
2	Systematic Review of Gut Microbiota and Major Depression. Front Psychiatry. 2019 Feb 11;10:34. doi: 10.3389/fpsyt.2019.00034. eCollection 2019.
3	Molecular Alteration Analysis of Human Gut Microbial Composition in Graves' disease Patients. Int J Biol Sci. 2018 Sep 7;14(11):1558-1570. doi: 10.7150/ijbs.24151. eCollection 2018.
4	Variability of core microbiota in newly diagnosed treatment-naive paediatric inflammatory bowel disease patients. PLoS One. 2018 Aug 13;13(8):e0197649. doi: 10.1371/journal.pone.0197649. eCollection 2018.
5	M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases. bioRxiv, 2019.
6	Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.Gut. 2020 Jul 10:gutjnl-2019-319706. doi: 10.1136/gutjnl-2019-319706. Online ahead of print.
7	Vitamin D receptor promotes healthy microbial metabolites and microbiome.Sci Rep. 2020 Apr 30;10(1):7340. doi: 10.1038/s41598-020-64226-7.
8	Host genetic variation impacts microbiome composition across human body sites.Genome Biol. 2015 Sep 15;16(1):191. doi: 10.1186/s13059-015-0759-1.
9	Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota. Pharmacol Res. 2019 Dec;150:104489. doi: 10.1016/j.phrs.2019.104489. Epub 2019 Nov 2.
10	Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow's milk allergy.Sci Rep. 2018 Aug 21;8(1):12500. doi: 10.1038/s41598-018-30428-3.

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