Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00613)
MIC Name Fusobacterium sp. (fusobacteria)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Species: Fusobacterium sp.
Oxygen Sensitivity Anaerobe
Microbial Metabolism Fermentative
Gram Negative
Host Relationship Commensal
Description Fusobacterium is a genus of anaerobic, Gram-negative, non-sporeforming bacteria, similar to Bacteroides. Strains of Fusobacterium cause several human diseases, including periodontal diseases, Lemierre's syndrome, and topical skin ulcers.
External Links Taxonomy ID
68766
GOLD Organism ID
Go0003586
Disease Relevance
          Colorectal cancer  [ICD-11: 2B91]
             Description Fusobacterium spp. was associated with colorectal cancer. [1]
          Ulcerative colitis  [ICD-11: DD71]
             Description Fusobacterium spp. was associated with ulcerative colitis. [1]
Host Genetic Factors (HGFs)
          A2ML1
             HGF ID HGF2326 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The duplication of A2ML1 could increase relative abundances of Fusobacterium (p-value<0.05). [2]
          SLC15A1
             HGF ID HGF2354 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of PepT1 could decrease the abundance of Fusobacterium. [3]
          rs878830
             HGF ID HGF1692 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs878830 SNP was significantly associated with the abundance of Fusobacterium (p-value=4.26E-06). [4]
          rs7299538
             HGF ID HGF2230 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7299538 SNP was significantly associated with the abundance of Fusobacterium (p-value=3.39E-06). [4]
          rs4903604
             HGF ID HGF1319 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4903604 SNP was significantly associated with the abundance of Fusobacterium (p-value=2.39E-07). [4]
          rs41419946
             HGF ID HGF1372 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs41419946 SNP was significantly associated with the abundance of Fusobacterium (p-value=3.26E-06). [4]
          rs325864
             HGF ID HGF1505 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs325864 SNP was significantly associated with the abundance of Fusobacterium (p-value=1.19E-06). [5]
          rs325863
             HGF ID HGF1504 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs325863 SNP was significantly associated with the abundance of Fusobacterium (p-value=1.19E-06). [5]
          rs2277524
             HGF ID HGF1697 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs2277524 SNP was significantly associated with the abundance of Fusobacterium (p-value=3.11E-06). [5]
          rs2225378
             HGF ID HGF2199 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs2225378 SNP was significantly associated with the abundance of Fusobacterium (p-value=3.56E-06). [4]
          rs11025278
             HGF ID HGF1489 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs11025278 SNP was significantly associated with the abundance of Fusobacterium (p-value=5.62E-06). [4]
          rs10498546
             HGF ID HGF1862 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10498546 SNP was significantly associated with the abundance of Fusobacterium (p-value=9.34E-06). [4]
          rs10489747
             HGF ID HGF1371 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10489747 SNP was significantly associated with the abundance of Fusobacterium (p-value=4.47E-06). [4]
          rs10132493
             HGF ID HGF2200 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs10132493 SNP was significantly associated with the abundance of Fusobacterium (p-value=3.56E-06). [4]
Host Immune Factors (HIFs)
          Immunoglobulin E
             HIF ID HIFM0271 HIF Info       Class Immunoglobulin (Ig)
             Description Fusobacterium is significantly enriched in IgE-mediated compared to non-IgE-mediated CMA(cows milk allergy) subjects. [6]
          CD4+ T cells
             HIF ID HIFC0069 HIF Info       Class T cells (TCs)
             Description Higher Fusobacterium relative abundance is independently associated with poorer CD4 T-cells responses. [7]
          FOXp3-CD45RA regulatory T cells
             HIF ID HIFC0202 HIF Info       Class T cells (TCs)
             Description The abundance of Fusobacterium was associated with the presence of FOXp3lowCD45RA Tregs. [8]
Environmental Factor(s)
             Disbiome ID
      77
             gutMDisorder ID
      gm0344
References
1 A diet change from dry food to beef induces reversible changes on the faecal microbiota in healthy, adult client-owned dogs. BMC Vet Res. 2017 May 30;13(1):147. doi: 10.1186/s12917-017-1073-9.
2 Middle ear microbiome differences in indigenous Filipinos with chronic otitis media due to a duplication in the A2ML1 gene.Infect Dis Poverty. 2016 Nov 1;5(1):97. doi: 10.1186/s40249-016-0189-7.
3 Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.NPJ Biofilms Microbiomes. 2020 Jul 21;6(1):27. doi: 10.1038/s41522-020-0137-y.
4 Genome-Wide Association Studies of the Human Gut Microbiota.PLoS One. 2015 Nov 3;10(11):e0140301. doi: 10.1371/journal.pone.0140301. eCollection 2015.
5 Host genetic variation impacts microbiome composition across human body sites.Genome Biol. 2015 Sep 15;16(1):191. doi: 10.1186/s13059-015-0759-1.
6 Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow's milk allergy.Sci Rep. 2018 Aug 21;8(1):12500. doi: 10.1038/s41598-018-30428-3.
7 Enrichment of gut-derived Fusobacterium is associated with suboptimal immune recovery in HIV-infected individuals. Sci Rep. 2018 Sep 24;8(1):14277. doi: 10.1038/s41598-018-32585-x.
8 Characterization of tumor-infiltrating immune cells in relation to microbiota in colorectal cancers. Cancer Immunol Immunother. 2020 Jan;69(1):23-32. doi: 10.1007/s00262-019-02433-6. Epub 2019 Nov 26.

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