Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00766)
MIC Name Leuconostoc mesenteroides (firmicutes)
MIC Synonyms Ascococcus mesenteroides
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Leuconostocaceae
Genus: Leuconostoc
Species: Leuconostoc mesenteroides
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Probiotic
Genome Size (bp) 2075763
Description Leuconostoc mesenteroides is a facultative anaerobe, Gram posotive nonsporogenous and non-motile species. It is a member of the lactic acid bacteria family. Leuconostoc mesenteroides should be considered as a potential cause of infective endocarditis and listed in the group of vancomycin-resistant microorganism.
External Links Taxonomy ID
1245
Genome Assembly ID
ASM51295v1
GOLD Organism ID
Go0003391
Disease Relevance
          Infectious endocarditis  [ICD-11: BB40]
             Description Leuconostoc mesenteroides should be considered as a potential cause of infective endocarditis and listed in the group of vancomycin-resistant microorganism. [1]
Host Immune Factors (HIFs)
          Interferon-12 subunit alpha
             HIF ID HIFM0130 HIF Info       Class Cytokine (Cyt)
             Description Leuconostoc mesenteroides induced the production of IL-12 expression. [2]
          Interferon-4
             HIF ID HIFM0149 HIF Info       Class Cytokine (Cyt)
             Description Leuconostoc mesenteroides could augment the production of IL-4 in vitro. [2]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description Stimulation with heat-killed Leuconostoc mesenteroides subsp. mesenteroides in mouse splenocytes induced the expression of IFN-Gamma, which was dependent on IL-12 production by Leuconostoc mesenteroides subsp. mesenteroides. [2]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Leuconostoc mesenteroides is associated with IgG immune responses. [2]
          Immunoglobulin E
             HIF ID HIFM0271 HIF Info       Class Immunoglobulin (Ig)
             Description Leuconostoc mesenteroides subsp. mesenteroides administration to mice, beginning either before or after the development of OVA sensitization, increased OVA-restimulated IFN-Gamma production in the splenocytes and reduced serum total and OVA-specific IgE levels. [2]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Leuconostoc mesenteroides is negatively associated with IgA. [3]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description The upregulation of IFN-gamma by LMM under the pro-Th2 conditions and the requirement of NF-kappaB, p38 and JNK for IL-12 production.These observations suggest that this microorganism can be a useful Th1-inducing agent in modulating the Th1.Th2 imbalance [2]
          Mitogen-activated protein kinase signaling pathway
             HIF ID HIFP0023 HIF Info       Class Signaling pathway (SP)
             Description Leuconostoc mesenteroides is associated with MAPK signaling. [2]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description Leuconostoc mesenteroides is associated with the activation of NF-kappaB signaling. [2]
          CD3+ T cells
             HIF ID HIFC0064 HIF Info       Class T cells (TCs)
             Description Leuconostoc mesenteroides is associated with CD3+ T-cells responses. [2]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description Leuconostoc mesenteroides can induce of Th1 cytokines under Th2-type conditions. [2]
          T helper type 2 cells
             HIF ID HIFC0085 HIF Info       Class T cells (TCs)
             Description Leuconostoc mesenteroides can induce of Th1 cytokines under Th2-type conditions. [2]
Environmental Factor(s)
             Disbiome ID
      557
             gutMDisorder ID
      gm0423
References
1 [Infectious endocarditis caused by Leuconostoc mesenteroides]. Enferm Infecc Microbiol Clin. 1998 May;16(5):237-8.
2 Induction of Th1 cytokines by Leuconostoc mesenteroides subsp. mesenteroides (KCTC 3100) under Th2-type conditions and the requirement of NF-kappaB and p38/JNK. Cytokine. 2009 May;46(2):283-9. doi: 10.1016/j.cyto.2009.02.005. Epub 2009 Mar 18.
3 Impact of a 3-Months Vegetarian Diet on the Gut Microbiota and Immune Repertoire.Front Immunol. 2018 Apr 27;9:908. doi: 10.3389/fimmu.2018.00908. eCollection 2018.

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