General Information of HIF (ID: HIFC0064)
HIF Name	CD3+ T cells
HIF Synonym(s)	CD3+ T-cell, CD3+ T cells
HIF Classification	T cells (TCs)
Description	CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3 chain, a CD3 chain, and two CD3 chains. These chains associate with the T-cell receptor (TCR) and the -chain (zeta-chain) to generate an activation signal in T lymphocytes. The TCR, -chain, and CD3 molecules together constitute the TCR complex.				[1]

Microbe Species (MIC) Regulated by This HIF
Candidatus Arthromitus sp. SFB-mouse (firmicutes)			MIC01824
Description	Segmented filamentous bacteria(SFB)-induced TNF-like ligand 1A drived intestinal CD3+ T cells activation during colitis.				[2]
Escherichia coli (enterobacteria)			MIC00516
Description	Escherichia coli-induced TNF-like ligand 1A drived intestinal CD3+ T cells activation during colitis.				[2]
Fusobacterium nucleatum (fusobacteria)			MIC00617
Description	High levels of infiltrating CD3+ cells have been associated with better patient prognosis in colorectal cancer with Fusobacterium nucleatum infection.				[3]
Haemophilus ducreyi (gamma-proteobacteria)			MIC00650
Description	Haemophilus ducreyi induced CD3 T cell infiltrate in the upper and midreticular dermis of papules.				[4]
Leuconostoc mesenteroides (firmicutes)			MIC00766
Description	Leuconostoc mesenteroides is associated with CD3+ T-cells responses.				[5]

References
1	A Novel T Cell-Engaging Bispecific Antibody for Treating Mesothelin-Positive Solid Tumors.Biomolecules. 2020 Mar 4;10(3):399. doi: 10.3390/biom10030399.
2	Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis.Immunity. 2018 Dec 18;49(6):1077-1089.e5. doi: 10.1016/j.immuni.2018.10.014. Epub 2018 Dec 11.
3	Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer. World J Gastroenterol. 2016 Jan 14;22(2):557-66. doi: 10.3748/wjg.v22.i2.557.
4	The immune response to Haemophilus ducreyi resembles a delayed-type hypersensitivity reaction throughout experimental infection of human subjects. J Infect Dis. 1998 Dec;178(6):1688-97. doi: 10.1086/314489.
5	Induction of Th1 cytokines by Leuconostoc mesenteroides subsp. mesenteroides (KCTC 3100) under Th2-type conditions and the requirement of NF-kappaB and p38/JNK. Cytokine. 2009 May;46(2):283-9. doi: 10.1016/j.cyto.2009.02.005. Epub 2009 Mar 18.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.