General Information of MIC (ID: MIC01824)
MIC Name	Candidatus Arthromitus sp. SFB-mouse (firmicutes)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Clostridiaceae Genus: Candidatus Arthromitus Species: Candidatus Arthromitus sp. SFB-mouse
Oxygen Sensitivity	Strictly anaerobe
Microbial Metabolism	Fermentative
Gram	Positive
Host Relationship	Commensal
Description	Candidatus Arthromitus sp. SFB-mouse or Candidatus Savagella is a member of the gut microbiota of rodents, fish and chickens, and has been shown to potently induce immune responses in mice.
External Links	Taxonomy ID	49118
	Genome Assembly ID	ASM27020v1
	GOLD Organism ID	Go0096767

Host Immune Factors (HIFs)
Immunoglobulin A
HIF ID	HIFM0272	HIF Info	Class	Immunoglobulin (Ig)
Description	Affinity-maturated IgA appear necessary for SFB(Segmented Filamentous Bacteria) pathobiont control.				[1]
CD3+ T cells
HIF ID	HIFC0064	HIF Info	Class	T cells (TCs)
Description	Segmented filamentous bacteria(SFB)-induced TNF-like ligand 1A drived intestinal CD3+ T cells activation during colitis.				[2]
T helper type 17 cells
HIF ID	HIFC0080	HIF Info	Class	T cells (TCs)
Description	Segmented filamentous bacteria (SFB) can induce a T helper type 17 (Th17) cells immune response.				[3]

Environmental Factor(s)
Disbiome ID			1150

References
1	The antibody/microbiota interface in health and disease.Mucosal Immunol. 2020 Jan;13(1):3-11. doi: 10.1038/s41385-019-0192-y. Epub 2019 Aug 14.
2	Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis.Immunity. 2018 Dec 18;49(6):1077-1089.e5. doi: 10.1016/j.immuni.2018.10.014. Epub 2018 Dec 11.
3	Microbiota in T-cell homeostasis and inflammatory diseases.Exp Mol Med. 2017 May 26;49(5):e340. doi: 10.1038/emm.2017.36.

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