Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0023)
HIF Name
Mitogen-activated protein kinase signaling pathway
HIF Synonym(s)
MAPK, MAPK signaling pathway
HIF Classification
Signaling pathway (SP)
Description The multifunctional mitogen-activated protein kinase (MAPK) signaling system consists of separate pathways that function to control a number of different cellular processes such as gene transcription, metabolism, motility, cell proliferation, apoptosis, synaptic plasticity and long-term memory [1]
Microbe Species (MIC) Regulated by This HIF
         Candida albicans (budding yeasts) MIC00317
             Description Candida albicans yeast cells are recognized by oral epithelial cells (in the TR146 cell line) and induce three signalling pathways within 15 min; the nuclear factor-kappaB (NF-kappaB) pathway, the phosphatidylinositol-4,5-bisphosphate 3-kinase (Pi3K), and all three mitogen-activated protein kinase (MAPK) pathways (p38, JNK (c-Jun N-terminal kinase) and ERK1/2 (extracellular signal-regulated protein kinase)). [2]
         Lactobacillus jensenii (firmicutes) MIC00720
             Description Lactobacillus jensenii TL2937 could inhibite MAPK signaling pathways. [3]
         Lactobacillus plantarum (firmicutes) MIC00730
             Description Lactobacillus plantarum was associated with MAPK signalling pathway. [4]
         Leuconostoc mesenteroides (firmicutes) MIC00766
             Description Leuconostoc mesenteroides is associated with MAPK signaling. [5]
         Listeria monocytogenes (firmicutes) MIC00771
             Description Listeria monocytogenes infection could active MAPK. [6]
References
1 Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis.J Recept Signal Transduct Res. 2015;35(6):600-4. doi: 10.3109/10799893.2015.1030412. Epub 2015 Jun 22.
2 Candida albicans-epithelial interactions and induction of mucosal innate immunity. Curr Opin Microbiol. 2017 Dec;40:104-112. doi: 10.1016/j.mib.2017.10.030. Epub 2017 Nov 17.
3 Modulation of Intestinal TLR4-Inflammatory Signaling Pathways by Probiotic Microorganisms: Lessons Learned from Lactobacillus jensenii TL2937. Front Immunol. 2014 Jan 14;4:512. doi: 10.3389/fimmu.2013.00512. eCollection 2014 Jan 14.
4 Short communication: Complete genome sequence of Lactobacillus plantarum J26, a probiotic strain with immunomodulatory activity. J Dairy Sci. 2019 Dec;102(12):10838-10844. doi: 10.3168/jds.2019-16593. Epub 2019 Sep 20.
5 Induction of Th1 cytokines by Leuconostoc mesenteroides subsp. mesenteroides (KCTC 3100) under Th2-type conditions and the requirement of NF-kappaB and p38/JNK. Cytokine. 2009 May;46(2):283-9. doi: 10.1016/j.cyto.2009.02.005. Epub 2009 Mar 18.
6 HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.

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