Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00720)
MIC Name Lactobacillus jensenii (firmicutes)
Body Site Vagina
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus jensenii
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Genome Size (bp) 1756479
Description Lactobacillus jensenii is a facultative anaerobic, Gram positive, non-spore forming, rod-shaped bacterium.
External Links Taxonomy ID
109790
Genome Assembly ID
ASM143645v1
GOLD Organism ID
Go0004170
Disease Relevance
          Vaginitis  [ICD-11: GA02]
             Description Lactobacillus jensenii was not significantly associated with Lactobacillus jensenii. [1]
Host Immune Factors (HIFs)
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Lactobacillus jensenii TL2937 was the strain with the highest capacity to down-regulate IL-6 production. [2]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Lactobacillus jensenii TL2937 was the strain with the highest capacity to down-regulate IL-8 production. [2]
          Mitogen-activated protein kinase signaling pathway
             HIF ID HIFP0023 HIF Info       Class Signaling pathway (SP)
             Description Lactobacillus jensenii TL2937 could inhibite MAPK signaling pathways. [2]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description Lactobacillus jensenii TL2937 could inhibite NF-B signaling pathways. [2]
          Toll like receptor 2 signalling pathway
             HIF ID HIFP0044 HIF Info       Class Signaling pathway (SP)
             Description The abundance of Lactobacillus jensenii TL2937 is associated with TLR2 signaling pathways. [2]
Environmental Factor(s)
             Disbiome ID
      474
             gutMDisorder ID
      gm0393
References
1 Association between vaginal washing and detection of Lactobacillus by culture and quantitative PCR in HIV-seronegative Kenyan women: a cross-sectional analysis. Sex Transm Infect. 2019 Sep;95(6):455-461. doi: 10.1136/sextrans-2018-053769. Epub 2019 Jan 29.
2 Modulation of Intestinal TLR4-Inflammatory Signaling Pathways by Probiotic Microorganisms: Lessons Learned from Lactobacillus jensenii TL2937. Front Immunol. 2014 Jan 14;4:512. doi: 10.3389/fimmu.2013.00512. eCollection 2014 Jan 14.

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