Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0010)
HIF Name	G-protein coupled receptor signaling pathway
HIF Synonym(s)	GPCR, GPCR signaling pathway
HIF Classification	Signaling pathway (SP)
Description	GPCR Signaling Pathways. G protein coupled receptors (GPCRs) are seven transmembrane (7TM) receptors that represent the largest family of membrane proteins present in eukaryotes. GPCRs comprise a single polypeptide that is folded into a spherical shape and retained in the plasma membrane.	[1]

Microbe Species (MIC) Regulated by This HIF
Mycoplasma pneumoniae (mycoplasmas)		MIC00875
Description	Thermobifida fusca was associated with GPCR.		[2]

References
1	G Protein-Coupled Receptor Signaling Through -Arrestin-Dependent Mechanisms.J Cardiovasc Pharmacol. 2017 Sep;70(3):142-158. doi: 10.1097/FJC.0000000000000482.
2	Data mining and systematic pharmacology to reveal the mechanisms of traditional Chinese medicine in Mycoplasma pneumoniae pneumonia treatment. Biomed Pharmacother. 2020 May;125:109900. doi: 10.1016/j.biopha.2020.109900. Epub 2020 Feb 3.

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