Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00365)
MIC Name Citrobacter koseri (enterobacteria)
MIC Synonyms Aerobacter diversum
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Citrobacter
Species: Citrobacter koseri
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Fermentative or Respiratory; Utilize citrate and a variety of other compounds
Gram Negative
Host Relationship Opportunistic pathogen
Genome Size (bp) 4735357
No. of Coding Genes 4794
No. of Non-Coding Genes 93
No. of Small Non-Coding Genes 93
No. of Gene Transcripts 4887
No. of Base Pairs 4975539
Description Citrobacter koseri is a facultatively anaerobic, Gram negative, non-spore-forming bacterium. C. koseri may act as an opportunistic pathogen in a variety of human infections.
External Links Taxonomy ID
545
Genome Assembly ID
PRJEB6512_assembly_1
GOLD Organism ID
Go0000060
Disease Relevance
          Peritonitis  [ICD-11: DC50]
             Description One case of Citrobacter koseri was the only reported case as the sole pathogen associated with a lethal retroperitoneal abscess in immunocompetent patient. [1]
Host Immune Factors (HIFs)
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description IgM responses to OSEs and NO-cysteinyl were significantly associated with IgA/IgM responses to Gram-negative bacteria, especially Morganella morganii, Klebsiella pneumoniae and Citrobacter koseri. [2]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description IgM responses to OSEs and NO-cysteinyl were significantly associated with IgA/IgM responses to Gram-negative bacteria, especially Morganella morganii, Klebsiella pneumoniae and Citrobacter koseri. [2]
          Myeloid differentiation primary response 88 signaling pathway
             HIF ID HIFP0026 HIF Info       Class Signaling pathway (SP)
             Description MyD88-dependent signals are critical for bacterial containment and inflammatory mediator production during Citrobacter koseri brain infection. [3]
          Toll-like receptor 4
             HIF ID HIFM0219 HIF Info       Class Toll-like receptor (TLR)
             Description The microglial activation by Citrobacter koseri is mediated by TLR4- and MyD88-dependent pathways. [3]
Environmental Factor(s)
             Disbiome ID
      1592
             gutMDisorder ID
      gm0178
References
1 A rare case of lethal retroperitoneal abscess caused by Citrobacter koseri. Urol Int. 2007;79(4):364-6. doi: 10.1159/000109725.
2 IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYCAT) pathway.Metab Brain Dis. 2017 Oct;32(5):1571-1583. doi: 10.1007/s11011-017-0040-2. Epub 2017 Jun 9.
3 MyD88 is pivotal for immune recognition of Citrobacter koseri and astrocyte activation during CNS infection. J Neuroinflammation. 2011 Apr 16;8:35. doi: 10.1186/1742-2094-8-35.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.