Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0139)
HIF Name
Interleukin-1 receptor type 1
HIF Synonym(s)
interleukin 1 receptor type 1, IL1R1, P80, IL1R, IL1RA, CD121A, D2S1473, IL-1R-alpha
HIF Classification
Cytokine (Cyt)
Molecular Function
Hydrolase; Receptor
Description IL-1RA is an agent that binds non-productively to the cell surface interleukin-1 receptor(IL-1R), the same receptor that binds interleukin 1 (IL-1), preventing IL-1from sending a signal to that cell. [1]
Pfam Immunoglobulin domain (PF13895 )
Immunoglobulin domain (PF18452 )
TIR domain (PF01582 )
Pathway Amoebiasis (hsa05146 )
Cytokine-cytokine receptor interaction (hsa04060 )
Fluid shear stress and atherosclerosis (hsa05418 )
Hematopoietic cell lineage (hsa04640 )
Human T-cell leukemia virus 1 infection (hsa05166 )
Human cytomegalovirus infection (hsa05163 )
Inflammatory mediator regulation of TRP channels (hsa04750 )
MAPK signaling pathway (hsa04010 )
NF-kappa B signaling pathway (hsa04064 )
Osteoclast differentiation (hsa04380 )
Pathogenic Escherichia coli infection (hsa05130 )
Shigellosis (hsa05131 )
Th17 cell differentiation (hsa04659 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
IL1R1_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Serratia marcescens (enterobacteria) MIC01171
             Description Serratia marcescens induces corneal inflammation by activation of the IL-1R1 pathway. [2]
References
1 Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy.Neurobiol Dis. 2017 Mar;99:12-23. doi: 10.1016/j.nbd.2016.12.007. Epub 2016 Dec 9.
2 Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.

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