Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0014)
HIF Name	Interleukin 1R1 signaling pathway
HIF Synonym(s)	IL-1R1 pathway, IL-1R1 signaling pathway
HIF Classification	Signaling pathway (SP)
Description	The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediatedmammary tumorigenesis and pulmonary metastasis	[1]

Microbe Species (MIC) Regulated by This HIF
Serratia marcescens (enterobacteria)		MIC01171
Description	Serratia marcescens can replicate in the cornea and cause severe keratitis, under conditions where the TLR/interleukin-1 receptor type 1 (IL-1R1) signaling pathway is impaired.		[2]

References
1	Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1/IL-1R1/MyD88/NF-B pathway.J Cell Mol Med. 2016 Nov;20(11):2064-2077. doi: 10.1111/jcmm.12898. Epub 2016 Jun 16.
2	Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.