Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00751)
MIC Name Legionella pneumophila (gamma-proteobacteria)
Body Site Lung
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Legionellales
Family: Legionellaceae
Genus: Legionella
Species: Legionella pneumophila
Oxygen Sensitivity Obligate aerobe
Microbial Metabolism Saccharolytic; Respiratory
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 3785576
No. of Coding Genes 3105
No. of Non-Coding Genes 47
No. of Small Non-Coding Genes 47
No. of Gene Transcripts 3152
No. of Base Pairs 3470989
Description Legionella pneumophila is an obligately aerobic, Gram negative bacterium. Legionnaires disease is the pneumonia caused by Legionella pneumophila.
External Links Taxonomy ID
446
Genome Assembly ID
ASM95067v1
GOLD Organism ID
Go0501396
Disease Relevance
          Legionnaires' disease  [ICD-11: 1C19]
             Description Legionella pneumophila was associated with legionnaires' disease. [1]
Host Genetic Factors (HGFs)
          rs5743854
             HGF ID HGF1260 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The rs5743854 G/G allele is associated with increased proinflammatory cytokine secretion after Legionella pneumophila infection. [2]
Host Immune Factors (HIFs)
          Interferon-18
             HIF ID HIFM0136 HIF Info       Class Cytokine (Cyt)
             Description The mice deficient for the IL-18 receptor are no more susceptible to Legionella pneumophila infection. [3]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description The secretion of IL-1beta is not required for response to Legionella pneumophila infection. [3]
          Interferon-1
             HIF ID HIFM0262 HIF Info       Class Cytokine (Cyt)
             Description Type I IFN can in response to Legionella pneumophila infection. [3]
          Nucleotide-binding oligomerization domain-containing protein 1
             HIF ID HIFM0184 HIF Info       Class Nod-like receptor (NLR)
             Description The NOD1 signaling can in response to Legionella pneumophila infection. [3]
          Nucleotide binding oligomerization domain containing 2 signaling pathway
             HIF ID HIFP0029 HIF Info       Class Signaling pathway (SP)
             Description NOD2 signaling can in response to Legionella pneumophila infection. [3]
          Monocyte differentiation antigen CD14
             HIF ID HIFM0037 HIF Info       Class T-cell receptor (TCR)
             Description Legionella pneumophila induced the expression of CD14 via TLR2. [3]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description Legionella pneumophila induced the expression of CD14 via TLR2. [3]
          Toll-like receptor 4
             HIF ID HIFM0219 HIF Info       Class Toll-like receptor (TLR)
             Description TLR4 is a general LPS sensor,which would recognize Legionella pneumophila. [3]
Environmental Factor(s)
             Disbiome ID
      1187
References
1 Current and emerging Legionella diagnostics for laboratory and outbreak investigations. Clin Microbiol Rev. 2015 Jan;28(1):95-133. doi: 10.1128/CMR.00029-14.
2 TOLLIP deficiency is associated with increased resistance to Legionella pneumophila pneumonia.Mucosal Immunol. 2019 Nov;12(6):1382-1390. doi: 10.1038/s41385-019-0196-7. Epub 2019 Aug 28.
3 Innate immunity to legionella pneumophila. Front Microbiol. 2011 May 16;2:109. doi: 10.3389/fmicb.2011.00109. eCollection 2011.

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