Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0136)
HIF Name
Interferon-18
HIF Synonym(s)
interleukin 18, IL18, IGIF, IL-18, IL-1g, IL1F4
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine
Description interleukin-18 (in't r-l'kin), A cytokine produced by macrophages; a potent inducer of interferon- by T cells and NK cells. [1]
Pfam Interleukin-1 / 18 (PF00340 )
Pathway African trypanosomiasis (hsa05143 )
Cytokine-cytokine receptor interaction (hsa04060 )
Cytosolic DNA-sensing pathway (hsa04623 )
Inflammatory bowel disease (IBD) (hsa05321 )
Influenza A (hsa05164 )
Legionellosis (hsa05134 )
Malaria (hsa05144 )
NOD-like receptor signaling pathway (hsa04621 )
Pathogenic Escherichia coli infection (hsa05130 )
Rheumatoid arthritis (hsa05323 )
Salmonella infection (hsa05132 )
Shigellosis (hsa05131 )
Tuberculosis (hsa05152 )
Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Yersinia infection (hsa05135 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
IL18_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Chlamydia pneumoniae (chlamydias) MIC00350
             Description The NLRP3 inflammasome can detect cellular stress induced by Chlamydophila pneumoniae infection, resulting in caspase-1 activation and production of IL-18 following priming by the TLR2/MyD88 pathway. [2]
         Clostridioides difficile (firmicutes) MIC00396
             Description Clostridium difficile toxin induced the production of IL-18. [3]
         Legionella pneumophila (gamma-proteobacteria) MIC00751
             Description The mice deficient for the IL-18 receptor are no more susceptible to Legionella pneumophila infection. [4]
         Rhodococcus hoagii (actinobacteria) MIC01092
             Description Rhodococcus equi is associated with the increasement of IL-18 expression. [5]
         Streptococcus thermophilus (firmicutes) MIC01272
             Description Streptococcus thermophilus 285 decreased mRNA expression IL-18. [6]
         Ureaplasma parvum (mycoplasmas) MIC01359
             Description Ureaplasma parvum is associated with IL-18 exprerssion. [7]
         Yersinia pestis (enterobacteria) MIC01401
             Description Yersinia pestis is associated with IL-18 expression. [8]
References
1 Interleukin 18 (IL-18) as a target for immune intervention.Acta Biochim Pol. 2016;63(1):59-63. doi: 10.18388/abp.2015_1153. Epub 2016 Feb 17.
2 Chlamydia pneumoniae Infection and Inflammatory Diseases. For Immunopathol Dis Therap. 2016;7(3-4):237-254. doi: 10.1615/ForumImmunDisTher.2017020161.
3 Performance of LBSap vaccine after intradermal challenge with L. infantum and saliva of Lu. longipalpis: immunogenicity and parasitological evaluation.PLoS One. 2012;7(11):e49780. doi: 10.1371/journal.pone.0049780. Epub 2012 Nov 26.
4 Innate immunity to legionella pneumophila. Front Microbiol. 2011 May 16;2:109. doi: 10.3389/fmicb.2011.00109. eCollection 2011.
5 Effects of age and macrophage lineage on intracellular survival and cytokine induction after infection with Rhodococcus equi. Vet Immunol Immunopathol. 2014 Jul 15;160(1-2):41-50. doi: 10.1016/j.vetimm.2014.03.010. Epub 2014 Mar 29.
6 Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells. PLoS One. 2020 Feb 11;15(2):e0228531. doi: 10.1371/journal.pone.0228531. eCollection 2020.
7 Different inflammatory responses are associated with Ureaplasma parvum-induced UTI and urolith formation. BMC Infect Dis. 2009 Jan 26;9:9. doi: 10.1186/1471-2334-9-9.
8 Immunology of Yersinia pestis Infection. Adv Exp Med Biol. 2016;918:273-292. doi: 10.1007/978-94-024-0890-4_10.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.