Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01359)
MIC Name Ureaplasma parvum (mycoplasmas)
MIC Synonyms Ureaplasma urealyticum biovar 1
Body Site Vagina
Lineage Kingdom: Bacteria
Phylum: Tenericutes
Class: Mollicutes
Order: Mycoplasmatales
Family: Mycoplasmataceae
Genus: Ureaplasma
Species: Ureaplasma parvum
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Utilize urea
Gram Positive
Host Relationship Pathogen; Commensal
Genome Size (bp) 751679
Description Ureaplasma parvum is a facultative anaerobic, Gram positive species of Ureaplasma. It was formerly known as Ureaplasma urealyticum biovar 1. Ureaplasma parvum has been identified as being a commensal in the uterus as part of the microbiome in healthy women of reproductive age.
External Links Taxonomy ID
134821
Genome Assembly ID
ASM671651v1
GOLD Organism ID
Go0002154
Disease Relevance
          Uterine inflammation  [ICD-11: GA01]
             Description Ureaplasma parvum colonized the amniotic fluid and caused uterine inflammation, but without overt chorioamnionitis. [1]
          Vaginitis  [ICD-11: GA02]
             Description Ureaplasma parvum was associated with bacterial vaginosis. [2]
Host Genetic Factors (HGFs)
          rs5743827
             HGF ID HGF1276 HGF Info       Class Single Nucleotide Polymorphism: Prime UTR variant (SNP-PV)
             Description The A allele of TLR6 rs5743827 reduced the risk for Ureaplasma respiratory tract colonization. [3]
          rs12750060
             HGF ID HGF1849 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12750060 SNP was significantly associated with the abundance of Ureaplasma parvum (p-value<1.00E-08). [4]
Host Immune Factors (HIFs)
          C-C motif chemokine 2
             HIF ID HIFM0022 HIF Info       Class Cytokine (Cyt)
             Description Ureaplasma parvum is associated with the MCP-1 expression. [5]
          Interferon-18
             HIF ID HIFM0136 HIF Info       Class Cytokine (Cyt)
             Description Ureaplasma parvum is associated with IL-18 exprerssion. [5]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description The abundance of Ureaplasma parvum is associated with IFN-gamma. [5]
Environmental Factor(s)
             Disbiome ID
      789
References
1 Intra-amniotic Ureaplasma parvum-Induced Maternal and Fetal Inflammation and Immune Responses in Rhesus Macaques. J Infect Dis. 2016 Nov 15;214(10):1597-1604. doi: 10.1093/infdis/jiw408. Epub 2016 Sep 6.
2 Mollicutes in vaginal microbiology: Mycoplasma hominis, Ureaplasma urealyticum, Ureaplasma parvum and Mycoplasma genitalium. Res Microbiol. 2017 Nov-Dec;168(9-10):875-881. doi: 10.1016/j.resmic.2017.02.009. Epub 2017 Mar 2.
3 Single nucleotide polymorphism in toll-like receptor 6 is associated with a decreased risk for ureaplasma respiratory tract colonization and bronchopulmonary dysplasia in preterm infants.Pediatr Infect Dis J. 2013 Aug;32(8):898-904. doi: 10.1097/INF.0b013e31828fc693.
4 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
5 Different inflammatory responses are associated with Ureaplasma parvum-induced UTI and urolith formation. BMC Infect Dis. 2009 Jan 26;9:9. doi: 10.1186/1471-2334-9-9.

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