| General Information of MIC (ID: MIC01092) |
| MIC Name |
Rhodococcus hoagii (actinobacteria)
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| MIC Synonyms |
Bacillus hoagii
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| Body Site |
Lung
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| Lineage |
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Nocardiaceae
Genus: Rhodococcus
Species: Rhodococcus hoagii
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| Oxygen Sensitivity |
Aerobe
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| Microbial Metabolism |
Saccharolytic
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| Gram |
Positive
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| Genome Size (bp) |
5043170
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| Description |
Rhodococcus equi is a Gram-positive coccobacillus bacterium. R. equi is an important pathogen causing pneumonia in foals. R. equi can also infect humans.
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| External Links |
Taxonomy ID |
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| Genome Assembly ID |
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| GOLD Organism ID |
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| Host Genetic Factors (HGFs) |
| rs1653301 |
| HGF ID |
HGF2132 |
HGF Info
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Class |
Single Nucleotide Polymorphism (SNP) |
| Description |
The rs1653301 SNP in mucosal immunity pathways influences the abundance of Rhodococcus in the upper airway (p-value=4.93E-03). |
[1] |
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| Host Immune Factors (HIFs) |
| Interferon-18 |
| HIF ID |
HIFM0136 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
Rhodococcus equi is associated with the increasement of IL-18 expression. |
[2] |
| Interferon-4 |
| HIF ID |
HIFM0149 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
Expression of IL-4 mRNA was significantly higher in monocyte-derived macrophages during Rhodococcus equi injection. |
[2] |
| Interferon-6 |
| HIF ID |
HIFM0151 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
Expression of IL-6 was significantly high(p<0.001)in bronchoalveolar macrophages during Rhodococcus equi infection. |
[2] |
| Tumor necrosis factor |
| HIF ID |
HIFM0226 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
The abundance of Rhodococcus equi is associated with TNF-Alpha. |
[2] |
| Immunoglobulin G |
| HIF ID |
HIFM0270 |
HIF Info
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Class |
Immunoglobulin (Ig) |
| Description |
Opsonisation by specific IgG was necessary for efficient phagocytosis of Rhodococcus equi by alveolar macrophages. |
[3] |
| Macrophages |
| HIF ID |
HIFC0020 |
HIF Info
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Class |
Macrophages (Mac) |
| Description |
Intracellular replication of Rhodococcus equi was associated with macrophages response. |
[2] |
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| Environmental Factor(s) |
| Disbiome ID |
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| gutMDisorder ID |
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| References |
| 1 |
Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.Microbiome. 2017 Feb 1;5(1):16. doi: 10.1186/s40168-016-0227-5.
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| 2 |
Effects of age and macrophage lineage on intracellular survival and cytokine induction after infection with Rhodococcus equi. Vet Immunol Immunopathol. 2014 Jul 15;160(1-2):41-50. doi: 10.1016/j.vetimm.2014.03.010. Epub 2014 Mar 29.
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| 3 |
The different effector function capabilities of the seven equine IgG subclasses have implications for vaccine strategies.Mol Immunol. 2008 Feb;45(3):818-27. doi: 10.1016/j.molimm.2007.06.158. Epub 2007 Jul 31.
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